肥胖患者血尿酸水平与骨骼肌、血脂的关系

Relationship between serum uric acid level and skeletal muscle,blood lipid in obese patients

目的分析肥胖患者的人体成分及血清代谢指标,并探讨肥胖患者发生高尿酸血症的影响因素。方法选取该院体检中心参加体检的人群作为研究对象,选取肥胖患者170例为肥胖组,根据血尿酸水平将其进一步分为高尿酸组和非高尿酸组;选取111例体质量指数(BMI)在正常范围的体检者作为对照组。测定并比较两组血清代谢相关指标[尿酸、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及空腹血糖(GLU)]、人体成分分析参数[BMI、体脂肪、体脂百分比、骨骼肌质量、腰臀比、内脏脂肪面积等]及高尿酸血症发生率;分析肥胖患者发生高尿酸血症的危险因素。结果肥胖组较对照组BMI、体脂肪、体脂百分比、骨骼肌质量、腰臀比、内脏脂肪面积、血清尿酸、TC、TG、LDL-C及GLU水平升高,而血清HDL-C水平明显降低,差异均有统计学意义(P<0.05)。肥胖组高尿酸血症的发生率高于对照组(P<0.05)。高尿酸组骨骼肌质量、TG水平明显高于非高尿酸组,而高尿酸组年龄、HDL-C水平低于非高尿酸组,差异均有统计学意义(P<0.05)。二分类多因素Logistic回归分析结果显示,骨骼肌质量和TG两个变量均是肥胖患者发生高尿酸血症的影响因素(P<0.05)。结论肥胖人群存在血清代谢异常及较高的高尿酸血症患病风险,肥胖患者骨骼肌质量、TG水平是发生高尿酸血症的影响因素。

Objective To analyze the body composition and serum metabolic indexes of obese patients,and to explore the influencing factors of hyperuricemia.Methods The population who participated in the physical examination center of the hospital were selected as the research objects,a total of 170 obese patients were selected as the obesity group,they were further divided into high uric acid group and non-high uric acid group according to the blood uric acid level.A total of 111 subjects with normal body mass index(BMI)were selected as the control group.Serum metabolism-related indexes[uric acid,total cholesterol(TC)、triacylglycerol(TG)、low density lipoprotein cholesterol(LDL-C),fasting blood glucose(GLU)],body composition analysis parameters[BMI,body fat,body fat percentage,skeletal muscle mass,waist hip ratio,visceral fat area,etc.]and the incidence of hyperuricemia were measured and compared between the two groups,and the influencing factors of hyperuricemia in obese patients were analyzed.Results Compared with the control group,the levels of BMI,body fat,body fat percentage,skeletal muscle mass,waist hip ratio and visceral fat area,serum uric acid,TC,TG,LDL-C and GLU in obesity group were increased,while the level of serum HDL-C was significantly decreased,with statistical significance(P<0.05).The incidence of hyperuricemia in obesity group was higher than that in control group(P<0.05).Skeletal muscle mass and TG levels in the high uric acid group were significantly higher than those in the non-high uric acid group,while age and HDL-C levels in the high uric acid group were lower than those in the non-high uric acid group,with statistical significance(P<0.05).The results of binary Logistic regression analysis showed that skeletal muscle mass and TG level were both influencing factors for hyperuricemia in obese patients(P<0.05).Conclusion Obese patients have abnormal serum metabolism and higher risk of hyperuricemia.Skeletal muscle mass and TG level are influencing factors of hyperuricemia in obese patients.