非酒精性脂肪性肝病进展中cGAS/STING信号通路激活及其免疫学作用

Activation of cGAS/STING signaling pathway and its immunological role in the progression of nonalcoholic fatty liver disease

非酒精性脂肪性肝病仍是当今最主要的慢性肝病。细胞DNA传感器环磷酸鸟-腺苷合成酶(cGAS)通过催化合成环磷酸鸟苷,激活干扰素基因刺激因子(STING),释放以I型干扰素为代表的细胞因子引发免疫反应。外源或内源DNA为cGAS配体激活cGAS-STING信号通路,在肝炎、非酒精性脂肪肝疾病、肝癌等疾病中发挥作用,通过自噬和代谢等机制影响肝病进展。现综述非酒精性脂肪肝疾病进展中cGAS-STING通路激活及其分子免疫学作用。

Today,nonalcoholic fatty liver disease remains the most dominant chronic liver disease.Cyclic guanosine monophosphate-adenosine monosphosphate synthase(cGAS)is a cytosolic DNA sensor that catalyzes the synthesis of cyclic guanosine monophosphate,activates stimulator of interferon genes(STING),and releases type-I interferon cytokines to trigger immune responses.Exogenous or endogenous DNA acts as a cGAS ligand to activate the cGAS-STING signaling pathway,which plays a role in hepatitis,nonalcoholic fatty liver disease,liver cancer and other diseases,and affects liver disease progression and metabolism through mechanisms such as autophagy.This article reviews the activation of cGAS-STING pathway and its molecular immunological role in nonalcoholic fatty liver disease progression.