趋化因子在动脉粥样硬化中的作用及研究进展

The Role and Research Progress of Chemokines in Atherosclerosis

动脉粥样硬化是一种累及中大型动脉的慢性炎症性疾病,是心血管疾病的潜在病因,其形成机制包括脂质沉积、单核细胞募集、泡沫细胞和纤维帽的形成。趋化因子及其受体密切调节着动脉粥样硬化斑块从形成致消退甚至破裂的整个过程。大量研究表明这个复杂的病理生理过程与趋化因子交互作用的功能多样性、细胞特异性和机体状态有关。这为寻找潜在的动脉粥样硬化治疗靶点带来困难。本文将对不同的趋化因子如何参与动脉粥样硬化病变发展的各个阶段做一综述。

Atherosclerosis is a chronic inflammatory disease involving medium and large arteries and a potential cause of cardiovascular disease,its formation mechanisms include lipid deposition,monocyte recruitment,foam cell and fibrous cap formation.Chemokines and their receptors closely regulate the whole process of atherosclerotic plaque formation,regression and even rupture.A large number of studies have shown that this complex pathophysiological process is related to the functional diversity,cell specificity and body state of chemokine interaction.This makes it difficult to find potential therapeutic targets for atherosclerosis.This article will review how different chemokines are involved in the development of atherosclerotic lesions.