坦索罗辛辅助腔镜手术对良性前列腺增生合并膀胱结石患者的临床研究

Clinical Study of Tamsulosin Assisted Endoscopic Surgery in Patients with Benign Prostatic Hyperplasia Complicated with Bladder Calculi

目的:探讨坦索罗辛辅助腔镜手术治疗良性前列腺增生(BPH)合并膀胱结石的临床效果。方法:选取2018年10月-2020年10月抚州市第一人民医院收治的BPH合并膀胱结石患者80例,按随机数字表法分为对照组和观察组,每组40例。对照组行经尿道肾镜碎石及前列腺等离子切除术(TUPKP)治疗,观察组在对照组基础上术后加用坦索罗辛治疗。比较两组临床疗效、术后康复情况、排尿情况、前列腺体积、国际前列腺症状评分(IPSS)、生活质量(QOL)评分、并发症及复发率。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组留置尿管时间、住院时间均短于对照组,差异均有统计学意义(P<0.05);观察组术后4周最大尿流率高于对照组,剩余尿量、前列腺体积、IPSS评分、QOL评分、复发率均低于对照组,差异均有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:坦索罗辛辅助腔镜手术可缩短BPH合并膀胱结石患者尿管留置时间,加快排尿功能及前列腺体积恢复,减轻排尿困难等症状,减少疾病复发,改善生活质量。

Objective:To investigate the clinical effect of Tamsulosin assisted endoscopic surgery in the treatment of benign prostatic hyperplasia (BPH) complicated with bladder calculi.Method:A total of 80 patients with BPH complicated with bladder calculi admitted to First People’s Hospital of Fuzhou from October 2018 to October 2020 were selected and divided into the control group and the observation group by random number table method,40 cases in each group.The control group was treated with transurethral nephrolithotompy and bipolar transurethral plasma kinetic prostatectomy (TUPKP),and the observation group was added with tamsulosin after operation on the basis of the control group.The clinical effect,postoperative recovery,urination,prostate volume,international prostate symptom score (IPSS),quality of life (QOL) score,complications and recurrence rates were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).The indurate catheter time and hospital stay in the observation group were shorter than those in the control group,the differences were statistically significant (P<0.05).The maximum urine flow rate 4 weeks after operation in the observation group was higher than that in the control group,and the residual urine volume,prostate volume,IPSS score,QOL score and recurrence rate were lower than those in the control group,the differences were statistically significant (P<0.05).There was no significant difference in complications between two groups (P>0.05).Conclusion:Tamsulosin assisted endoscopic surgery can shorten the indwelling time of urinary duct,accelerate the recovery of urination function and prostate volume,relieve dysuria and other symptoms,reduce disease recurrence and improve the quality of life in patients with BPH complicated with bladder calculi.