基于阻断蛋白质相互作用的抗肿瘤多肽研究进展

Research progress of anti-tumor peptides based on blocking protein-protein interactions

肿瘤的发病率在逐年增长,其中恶性肿瘤严重影响着人类的健康和生命。目前,临床上常规抗癌药物由于存在靶向性较低、毒副作用明显、容易产生耐药性等缺点,正在失去其一些治疗用途。而抗肿瘤多肽类药物拥有分子量小、靶向性强、特异性高、毒性弱、易于合成等特点,使其成为了治疗肿瘤的新方法。抗肿瘤多肽主要包括天然多肽、人工修饰多肽及人工合成多肽,其作用机制非常复杂,主要包括抑制肿瘤细胞增殖、迁移和侵袭,促肿瘤细胞凋亡,免疫调节等。该文从多肽通过阻断蛋白质相互作用发挥抗肿瘤作用这一机制进行概述。

The incidence of cancer is increasing year by year,and malignant tumors seriously affect human health and life.At present,conventional anticancer drugs are losing some therapeutic applications due to their low targeting,obvious toxic and side effects,and drug resistance.The anti-tumor polypeptide drugs have the characteristics of small molecular weight,high specificity,weak toxicity,easy synthesis and so on,which makes them become a new drug for treatment of tumor.Antitumor peptides mainly include natural peptides,artificial modified peptides and synthetic peptides.Its mechanism of anti-tumor is very complex,including inhibition of tumor cell proliferation,migration and invasion,promotion of tumor cell apoptosis and immunoregulation.In this review,an overview of anti-tumor peptides based on blocking protein-protein interactions will be presented.