乌灵胶囊联合正念减压治疗躯体化障碍临床研究

Clinical Study of Wuling Capsules Combined with Mindfulness Decompression in the Treatment of Somatization Disorder

目的探讨乌灵胶囊联合正念减压治疗躯体化障碍的临床疗效。方法选取医院2019年6月至2020年6月收治的躯体化障碍患者152例,随机分为观察组和对照组,各76例。两组患者均给予正念减压治疗,观察组患者加服乌灵胶囊。两组患者均持续治疗12周。结果观察组自愿退出1例、失访2例、未严格执行治疗方案2例,对照组失访3例、临床检测数据缺失2例、自愿退出1例,均剔除。观察组总有效率为90.14%,显著高于对照组的75.71%(P<0.05);观察组治疗依从性各项评分均显著高于对照组(P<0.05);观察组事件相关电位P300 P2波、P3波的潜伏期均显著短于对照组,P2波、P3波波幅均显著高于对照组(P<0.05);观察组生活质量评分显著高于对照组(P<0.05)。观察组和对照组患者不良反应发生率相当(15.49%比8.57%,P>0.05)。结论乌灵胶囊联合正念减压治疗躯体化障碍,可改善患者的依从性、生活质量及电生理指标。

Objective To investigate the clinical efficacy of Wuling Capsules combined with mindfulness decompression in the treatment of somatization disorder.Methods A total of 152 patients with somatization disorder admitted to the hospital from June 2019 to June 2020 were selected and randomly divided into the observation group and the control group,with 76 cases in each group.The patients in the two groups were treated with mindfulness decompression,on this basis,the patients in the observation group were treated with Wuling Capsules.Both groups were continuously treated for 12 weeks.Results One case voluntary withdrew,two cases were lost to of follow-up,two cases did not strictly implement the treatment plan in the observation group,while three cases were lost to follow-up,two cases were lack of clinical test data and one case voluntary withdrew in the control group,all of them were excluded.The total effective rate in the observation group was 90.14%,which was significantly higher than 75.71%in the control group(P<0.05).The scores of treatment compliance in the observation group were significantly higher than those in the control group(P<0.05).The latency of P2 wave and P3 wave of event-related potential P300 in the observation group was significantly shorter than that in the control group,while the amplitude of P2 wave and P3 wave in the observation group was significantly higher than that in the control group(P<0.05).The score of quality of life in the observation group was significantly higher than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.49%vs.8.57%,P>0.05).Conclusion Wuling Capsules combined with mindfulness decompression in the treatment of somatization disorder can improve patients′compliance,quality of life and electrophysiological indexes.