基于ClinicalTrials.gov数据分析美国军方野战输血的主要研究方向

Analysis of the main research directions in transfusion of the U.S.military based on ClinicalTrials.gov data

目的 了解美国军队野战输血医学发展的主要方向和最新动态。方法 通过www.clinicaltrials.gov网站首页,以“United States Department of Defense”“U.S.Army Medical Research and Development Command”“United States Naval Medical Research Center”为检索词,检索自ClinicalTrials.gov成立(2002年)起至2021年5月1日野战输血医学相关临床试验项目的完整备案信息,通过研究进展状态、临床分期、任务分配、地域分布和主要研究内容及研究成果等,分析其主要特点。结果 共检索到临床试验项目931项,与野战输血医学密切相关的有16项;其中全血病原体处置占25%(4/16)、血小板输注占25%(4/16)、血浆输注占25%(4/16)、全血输注占18.75(3/16)和其他类型研究占6.25%(1/16)。美国军方注重在血液安全、血液贮存等方面的新技术突破,在抗休克输血输液治疗方面的效果评价,在全血早期输注治疗方面的应用探索和在血液保障技术产品研发方面的军地互动优势。结论 基于ClinicalTrials.gov对美国军方野战输血医学的分析,有利于快速了解美国军队野战输血医学的发展现状和趋势。

Objective To explore the main development directions and research progress of blood transfusion in the U.S.military based on ClinicalTrials.gov.Methods The literature of clinical trials related to field transfusion medicine from 2002 to 2021 were retrieved based on www.clinicaltrials.gov with “United States Department of Defense”,“U.S.Army Medical Research and Development Command” and “United States Naval Medical Research Center” as the search terms, and the main characteristics were analyzed in terms of research progress, clinical stage, task allocation, regional distribution, research contents and results.Results A total of 931 clinical trials were retrieved, of which 16 were closely related to field blood transfusion medicine.Among them, pathogen reduction/inactivation of whole blood, platelet transfusion, plasma transfusion, whole blood transfusion and other types of researches accounted for 25%(4/16),25%(4/16),25%(4/16),18.75(3/16) and 6.25%(1/16),respectively.The U.S.military focused on the new technological breakthroughs in blood safety and blood storage, the evaluation of the countershock therapy, the application of whole blood early transfusion and the civil-military inosculation in research.Conclusion This study, based on ClinicalTrials.gov data, redounds to understand the research progress and current situation of the U.S.military field blood transfusion medicine.