炎性细胞因子在肌萎缩侧索硬化诊断治疗中的研究进展

Research progress of inflammatory cytokines in the diagnosis and treatment of amyotrophic lateral sclerosis

肌萎缩侧索硬化(ALS)是一种多个基因参与的复杂疾病,涉及多种机制。神经炎性反应是其中机制之一,有许多炎性细胞因子参与,其有可能作为生物标志物及治疗靶点应用于临床。突变基因编码的许多蛋白质可损害免疫系统功能,导致免疫功能失调,驱动中枢神经系统和外周免疫系统的炎性反应。炎性细胞因子种类较多,水平变化较大,受疾病阶段、类型及共病影响,目前在ALS中的结果尚不一致,无单一炎性细胞因子可做为特异标志物。炎性细胞因子做为治疗监测标志物及靶点有一定前景。

Amyotrophic lateral sclerosis(ALS)is a multifactor,multiple genes disease which involving a variety of mechanisms.Neuroinflammatory response is one of the mechanisms.Many inflammatory cytokines are involved.It may be used in clinic as biomarkers and therapeutic targets.Many proteins encoded by mutant genes can damage the function of immune system,lead to immune dysfunction and drive the inflammatory response of central nervous system and peripheral immune system.There are many kinds of inflammatory cytokines with great diversification in their levels which influenced by the stage,type and comorbidity of the disease,the results are not consistent at present,and there is no single inflammatory cytokine identified as a specific marker.Inflammatory cytokines have a certain prospect as therapeutic monitoring markers and targets.