苓甘五味姜辛汤联合止咳散治疗慢性咳嗽伴睡眠障碍的疗效及对患者症状改善及睡眠质量的影响

Effect of Linggan Wuwei Ginger Xin Decoction Combined with Zhike Powder in the Treatment of Chronic Cough with Sleep Disorder and its Effect on Symptom Improvement and Sleep Quality of Patients

目的:探究苓甘五味姜辛汤与止咳散联合治疗慢性咳嗽伴睡眠障碍的疗效及对患者症状改善及睡眠质量的影响。方法:选取2019年8月至2020年12月茂名市职业病防治院收治的慢性咳嗽伴睡眠障碍患者156例作为研究对象,按照随机数字表法分为对照组和观察组,每组78例。对照组以复方甘草合剂治疗,观察组则以苓甘五味姜辛汤与止咳散联合治疗,比较2组治疗有效率、治疗前后症状评分及匹兹堡睡眠质量指数(PSQI)评分和不良反应发生率。结果:治疗后观察组症状评分及PSQI评分和不良反应发生率均低于对照组,总有效率高于对照组,对照组患者的痰量、咳嗽、神疲乏力和气短胸闷等中医证候积分高于观察组,且对照组咳嗽消失时间长于观察组,差异有统计学意义(P<0.05)。结论:慢性咳嗽伴睡眠障碍患者采用苓甘五味姜辛汤与止咳散联合治疗的疗效显著,可显著改善咳嗽症状,无明显不良反应,提升睡眠质量,值得大力推广。

Objective:To explore the efficacy of linggan Wuwei Jiangxin decoction combined with Zhike powder in the treatment of chronic cough with sleep disorder and its effect on the improvement of symptoms and sleep quality.Methods:A total of 156 patients with chronic cough and sleep disorders who were admitted to Maoming Occupational Disease Prevention and Control Hospital from August 2019 to December 2020 were selected as the research objects,and they were randomly divided into the control group and the observation group,with 78 cases in each group.The control group was treated with Compound Gancao Mixture,while the observation group was treated with Linggan Wuwei Jiangxin Decoction and Zhike Powder.The treatment efficacy,symptom scores before and after treatment,Pittsburgh Sleep Quality Index(PSQI)score and incidence of adverse reactions were compared between the two groups.Results:After treatment,the symptom score,PSQI score and the incidence of adverse reactions in the observation group were lower than those in the control group,and the total effective rate was higher than that in the control group,and the cough disappeared time in the control group was longer than that in the observation group,and the difference was statistically significant(P<0.05).Conclusion:The combination of linggan Wuwei Jiangxin Decoction and Zhike powder in the treatment of patients with chronic cough with sleep disorder can significantly improve cough symptoms,have no obvious adverse reactions and improve sleep quality,which is worthy of vigorous promotion.