基于“肝肾同源”理论探讨OPG/RANKL/RANK信号系统在骨转移癌痛中的调控机制

OPG/RANKL/RANK Signaling Regulation Mechanism of Cancer-induced Bone Pain Based on"the Same Source of Liver and Kidney"Theory

从肝肾同源理论的应用出发,结合骨保护素(osteoprotegerin,OPG)/核因子受体活化因子NF-κB配体(receptor activator of NF-κB ligand,RANKL)/NF-κB受体活化因子(receptor activator for NF-κB,RANK)信号系统在骨代谢中的调控机制,阐释肝肾同源理论应用于临床的客观分子生物学依据,更好地指导临床。

Objective molecular biological evidence of applying"the same source of liver and kidney"is explained on the foundation of the application of the theory,combined with the regulatory mechanism of OPG/RANKL/RANK signaling system in bone metabolism,in order to better guide clinical prevention and treatment of bone metastasis cancer pain.