急性髓系白血病动物模型及中药干预的研究进展

Research progress of acute myeloid leukemia animal models and intervention with traditional Chinese medicine

急性髓系白血病(acute myeloid leukemia,AML)是一种恶性增殖性疾病,发病机制尚未明确,目前临床治疗措施有限且进展缓慢。中药治疗AML具有一定优势,但其作用机制仍有待深入探讨。理想的实验动物模型有助于揭示AML发生发展的关键机制,对于潜在靶点的发现、治疗方法的开发及中药抗AML机制的研究至关重要。近年来,众多学者为阐明AML的发病机制及中药抗AML作用机制做了大量研究,并取得相关成果。在此基础上,本文系统总结了AML实验动物的选择、动物模型的制备方法以及各自的特点和评价方法,并总结了AML动物模型的中药干预研究进展,为今后AML动物模型研究及中医药治疗AML提供理论参考。

Acute myeloid leukemia(AML)is a malignant proliferative disease,and its pathogenesis is not clear,which led to the limited and tardy progress of treatment measures.Traditional Chinese medicine(TCM)has certain advantages in the treatment of AML,but its mechanism of action needs further exploration.The ideal experimental animal model is helpful to reveal the key mechanism of the occurrence and development of AML and play an important role in the discovery of potential targets,the development of therapeutic approaches and the study of anti-AML mechanism of TCM.In recent years,many scholars have done a lot of research to elucidate the pathogenesis of AML and the mechanism of anti-AML action of TCM,which have achieved relevant results.On this basis,this review summarizes the selection of experimental animals for AML,animal model preparation methods for AML,as well as their respective advantages and disadvantages and evaluation methods,and summarizes the research progress of TCM intervention in animal models of AML,providing theoretical reference for future research on animal models of AML and TCM treatment of AML.