NLRP3炎症小体与中药提取物调节脑脊髓疾病机制

Mechanism of NLRP3 inflammasome and traditional Chinese medicine extract on regulation of cerebrospinal diseases

NLRP3炎症小体是炎症反应过程中极为重要的因子,能参与多种疾病尤其是脑脊髓疾病的发生发展过程,可干预中枢神经系统的调节与恢复。大量研究表明,中药相应提取物对NLRP3具有良好调节作用。本文就NLRP3炎症小体启动与激活过程,在脊髓损伤、动脉粥样硬化、抑郁症、缺血性脑卒中等脑脊髓疾病中的机制效应,以及中药提取物治疗相应疾病的动物实验研究进行综述,为临床调节NLRP3炎症小体提供有效依据。

NLRP3 inflammasome is a very important factor in the process of inflammatory response.It can participate in the occurrence and development of a variety of diseases,especially cerebrospinal diseases,and can intervene in the regulation and recovery of the central nervous system.A large number of studies have shown that traditional Chinese medicine and its corresponding extracts have a good regulatory effect on NLRP3.This article mainly reviews the start-up and activation process of NLRP3 inflammasome,and its mechanism effects of cerebrospinal diseases such as spinal cord injury,atherosclerosis,depression and ischemic stroke,as well as the animal experimental studies of traditional Chinese medicine extracts in the treatment of these diseases,so as to provide effective basis for clinical regulation of NLRP3 inflammasome.