摘要
抗体药物是一种可与相应抗原发生特异性结合的免疫球蛋白。该研究从抗体药物的结构入手,对抗体药物的药物代谢动力学基本特点进行综述,并着重介绍了其不同于小分子药物的独特代谢特征,主要包括与靶点介导的药物处置、新生儿Fc受体介导的循环再利用、糖基化修饰和电荷异质性对清除速率的影响以及与抗药物抗体相结合导致清除加快。最后总结了纳米抗体、双特异性抗体、抗体药物偶联物等新型抗体药物的药物代谢动力学研究进展。
Antibody drugs are immunoglobulins that can specifically bind to corresponding antigens.In this review,we start with the structure of antibody drugs and review the basic characteristics of the pharmacokinetics of antibody drugs.We highlight the unique metabolic characteristics of antibody drugs that differ from small molecule drugs,mainly including target-mediated drug disposition,neonatal Fc receptor-mediated recycling,glycosylation modifications and the effect of charge heterogeneity on clearance rates,and binding to anti-drug antibodies leading to accelerated clearance.Finally,the research progress on the pharmacokinetics of new antibody drugs,such as nanobodies,bispecific antibodies,and antibody-drug conjugates,is summarized.
作者
张金桂
王超
ZHANG Jingui;WANG Chao(PhaseⅠClinical Trial Ward,Hainan General Hospital,Haikou,Hainan 570311,China;Department of Pharmacy,Hainan General Hospital,Haikou,Hainan 570311,China)
出处
《安徽医药》
CAS
2022年第7期1282-1286,I0001,共6页
Anhui Medical and Pharmaceutical Journal