侵袭性脑膜瘤的诊断及研究进展

Diagnosis and Research Progress of Invasive Meningioma

脑膜瘤是一种极为常见的成人颅脑肿瘤,该病的患病率约占所有颅脑肿瘤的30%,多数为良性的WHOⅠ级肿瘤,少数为WHOⅡ~Ⅲ级肿瘤。部分脑膜瘤可观察到肿瘤向邻近硬脑膜、蛛网膜及蛛网膜下腔侵犯,或镜下在邻近骨骼、肌肉、脑组织标本中找到肿瘤细胞,称为侵袭性脑膜瘤。侵袭性脑膜瘤的生物学特性、诊断及治疗与非侵袭性脑膜瘤略有不同,术后复发率、病死率也较非侵袭性脑膜瘤明显升高。2016年中枢神经系统肿瘤WHO分类中,首次将脑膜瘤脑浸润列为脑膜瘤WHO分类标准之一。本文就侵袭性脑膜瘤的诊断、影像学评估、治疗及相关研究进展展开讨论。

Meningioma is an extremely common adult brain tumor, the prevalence of this disease accounts for about 30% of all brain tumors, most of which are benign WHOⅠtumors, and a few are WHO Ⅱ-Ⅲ tumors. some meningiomas can be observed to invade the adjacent dura mater, arachnoid and subarachnoid space, or find tumor cells in adjacent bone, muscle, and brain tissue specimens under the microscope, which is called invasive meningioma. The biological characteristics, diagnosis and treatment of aggressive meningioma are slightly different from those of non-invasive meningioma, and the postoperative recurrence rate and mortality rate are also significantly higher than those of non-invasive meningioma. In 2016, the WHO classification of central nervous system tumors listed meningioma brain infiltration as one of the WHO classification criteria for meningioma for the first time. This article discusses the diagnosis, imaging evaluation, treatment and related research progress of aggressive meningioma.