基于“浊毒”理论探讨大动脉粥样硬化型脑梗死病机及其中医药治疗进展

Pathogenesis and Progress of Traditional Chinese Medicine Treatment of Large Atherosclerotic Cerebral Infarction Based on"Turbid Toxin"Theory

大动脉粥样硬化型脑梗死是我国最常见的脑梗死亚型,病机复杂,复发率高。近年来基于其病机的中西医研究不断深入。本文结合大动脉粥样硬化型脑梗死“动脉-动脉栓塞、低灌注、穿支动脉受累”等西医病机,回顾了“浊毒”理论的形成过程及基本特点,指出大动脉粥样硬化型脑梗死中医病机为“浊毒伏脉,胶结痰瘀”,提出了“化浊解毒、益气散瘀通络”的治疗原则,并综述了近年来相关中医药治疗研究进展以为此治疗原则提供依据。本文丰富了大动脉粥样硬化型脑梗死的中医病机,为其中医治疗方案的选择提供了更多依据。

Large atherosclerotic cerebral infarction is the most common subtype of cerebral infarction in China,with complex pathogenesis and high recurrence rate.In recent years,the research of traditional Chinese and western medicine based on its pathogenesis has been deepening.Based on the western medical pathogenesis of large atherosclerotic cerebral infarction,such as"arterial arterial embolism,low perfusion and perforator artery involvement",this paper reviews the formation process and basic characteristics of the theory of"turbid toxin",points out that the TCM pathogenesis of large arterial atherosclerotic cerebral infarction is"turbid toxin adjoins artery,cement phlegm and blood stasis",puts forward the treatment principle of"removing turbid toxin,detoxifying Qi,dissipating blood stasis and clearing collaterals",and reviews the research progress of related TCM treatment in recent years to provide the basis for this treatment principle.This paper enriches the TCM pathogenesis of large artery atherosclerotic cerebral infarction,and provides more basis for the selection of TCM treatment program.