多磺酸黏多糖乳膏协同硝酸舍他康唑乳膏治疗鳞屑角化型足癣的临床疗效

Clinical efficacy of mucopolysaccharide polysulfate cream in combination with sertaconazole nitrate cream in the treatment of scaly hyperkeratotic tinea pedis

目的探讨多磺酸黏多糖乳膏协同硝酸舍他康唑乳膏治疗鳞屑角化型足癣的疗效。方法采用随机数字表法将2019年3月至2020年1月鳞屑角化型足癣患者100例平均分为2组:对照组单纯外用硝酸舍他康唑乳膏0.5~1g/次,每天2次;联合组先外用多磺酸黏多糖乳膏0.5~1 g/次,30 min后再外用硝酸舍他康唑乳膏0.5~1g/次,每天2次。共治疗4周。比较2组临床症状缓解时间、疗效及不良反应发生率,于治疗0、2、4周分析2组皮肤病生活质量指数(DLQI)评分。统计分析采用两独立样本t检验及重复测量方差分析。结果治疗后,联合组瘙痒及脱屑缓解时间分别为(6.05±1.98)d、(12.03±3.92)d,显著短于对照组[(8.39±2.11)d、(15.11±4.05)d,t值分别为5.72、3.86,均P<0.001]。4周治疗期间,两组DLQI评分均逐渐下降(均P<0.001),治疗2、4周时联合组DLQI评分均显著低于对照组(P<0.001)。治疗4周后,联合组总有效率为98%,显著高于对照组(82%),χ^(2)=7.11,P=0.007;两组不良反应发生率差异无统计学意义(P>0.05)。结论多磺酸黏多糖乳膏可提高硝酸舍他康唑乳膏治疗鳞屑角化型足癣的疗效。

Objective To investigate clinical efficacy of mucopolysaccharide polysulfate cream combined with sertaconazole nitrate cream in the treatment of scaly hyperkeratotic tinea pedis.Methods From March 2019 to January 2020,100 patients with scaly hyperkeratotic tinea pedis were enrolled into this study,and randomly and equally divided into 2 groups by using a random number table:control group treated with topical sertaconazole nitrate cream alone at a dose of 0.5-1 g twice a day;combined group treated with topical mucopolysaccharide polysulfate cream at a dose of 0.5-1 g followed by topical sertaconazole nitrate cream at a dose of 0.5-1 g 30 minutes later,which were performed twice a day.The treatment lasted 4 weeks.The time to clinical symptom relief,efficacy and incidence of adverse reactions were compared between the two groups.Dermatology life quality index(DLQI)was assessed at 0,2 and 4 weeks after the start of treatment.Two-independent-sample t test,repeated measures analysis of variance and chi-square test were used for statistical analysis.Results After treatment,the time to pruritus relief and that to desquamation improvement were 6.05±1.98 and 12.03±3.92 days respectively in the combined group,which were significantly shorter than those in the control group(8.39±2.11,15.11±4.05 days,t=5.72,3.86,respectively,both P<0.001).During the 4 weeks of treatment,DLQI scores gradually decreased in both the 2 groups(all P<0.001),which were significantly lower in the combined group than in the control group at weeks 2 and 4(both P<0.001).After 4-week treatment,the total response rate was 98%(49/50)in the combined group,significantly higher than that in the control group(82%,41/50;χ^(2)=7.11,P=0.007).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Mucopolysaccharide polysulfate cream can improve the efficacy of sertaconazole nitrate cream in the treatment of scaly hyperkeratotic tinea pedis.