靶向巨噬细胞表面受体治疗炎症性肠病的研究进展

Research progress of targeting macrophage surface receptors in the treatment of inflammatory bowel disease

炎症性肠病(IBD),包括溃疡性结肠炎(UC)和克罗恩病(CD),是一种病因和机制不明的肠道慢性炎症疾病。在IBD患者肠道组织中,巨噬细胞调节受损导致肠道持续炎症。巨噬细胞具有高度可塑性,微环境中的各种因子通过配体受体结合的方式来调控其表型和功能,从而影响结肠炎的转归。

Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohns disease(CD),is a chronic inflammatory disorder of the gastrointestinal tract with unknown etiology and pathogenesis.In the intestinal tissues of IBD patients,dysregulation of macrophages results in persistent intestinal inflammation.Macrophages are highly adaptable and their phenotypes and functions could be regulated by various factors in the microenvironment via ligand-receptor binding,thus affecting the progression of the disease.