基于偏振敏感光学相干层析术的口腔鳞状细胞癌组织成像

Polarization-Sensitive Optical Coherence Tomography for Oral Squamous Cell Carcinoma Tissue Imaging

口腔鳞状细胞癌(OSCC)发病率较高且预后效果有限,早期诊断和术中准确识别病变边界对于改善预后效果具有重要意义。偏振敏感光学相干层析术(PS-OCT)在获得组织微观结构信息的同时,可以获得组织的偏振信息,提高组织诊断的特异性。为验证PS-OCT技术在OSCC诊断应用中的可行性,利用自行开发的高分辨率PS-OCT系统对离体的OSCC组织进行了成像。初步的成像结果表明,与正常组织相比,OSCC具有明显的双折射特性,利用累积相位延迟可以明显地区分正常组织和癌组织。最终证明,高分辨率的PS-OCT技术在OSCC组织的识别诊断和边界检测方面具有很大的潜力,可以辅助医生进行疾病的筛查和术中边界检测。

Oral squamous cell carcinoma(OSCC)has a high incidence and limited prognosis,and it is of great significance to improve the prognosis by early diagnosis and accurate identification of the lesion boundaries during surgery.Polarization-sensitive optical coherence tomography(PS-OCT)can not only obtain tissue microstructure information,but also obtain tissue polarization information,which can improve the specificity of tissue diagnosis.In order to verify the feasibility of PS-OCT technology in the diagnosis of OSCC,a self-developed high-resolution PS-OCT system is used to image OSCC tissue ex vivo.The preliminary imaging results show that OSCC has an obvious birefringence effect compared with the normal tissue,and the accumulative phase retardation can be used to distinguish normal tissues and cancerous tissues.Finally,it is proved that high-resolution PS-OCT technology has great potential for identification,diagnosis,and boundary detection of OSCC tissue.In addition,it can assist surgeons in disease screening and intraoperative boundary detection.