糖皮质激素鼻喷雾剂联合地氯雷他定治疗小儿过敏性鼻炎效果及对免疫球蛋白、炎症因子水平的影响

Effect of glucocorticoid nasal spray combined with desloratadine on allergic rhinitis in children and its effects on immunoglobulin and inflammatory factors

目的 探究糖皮质激素鼻喷雾剂联合地氯雷他定治疗小儿过敏性鼻炎效果及对炎症因子水平的影响。方法 选取我院2019年3月-2020年3月期间收治的100例小儿过敏性鼻炎患者,随机数字法将其分为观察组和对照组各50例,对照组患者给予地氯雷他定治疗,观察组患者给予糖皮质激素鼻喷雾剂联合地氯雷他定治疗,对比两组患者的临床治疗效果、炎症因子水平以及不良反应发生情况。结果 观察组的临床有效率为96.00%显著高于对照组的临床有效率78.00%;治疗后观察组在 IL-6、IgE指标较对照组降低显著,在IgA指标较对照组显著增高;观察组的不良反应发生率为6.00%,显著低于对照组的不良反应发 生率22.00%,P<0.05表示差异具有统计意义。结论 糖皮质激素鼻喷雾剂联合地氯雷他定治疗小儿过敏性鼻炎临床效果显著,且有效的调节炎症因子,降低不良反应。

Objective To explore the effect of glucocorticoid nasal spray combined with desloratadine on allergic rhinitis in children and its effect on inflammatory factors.Methods 100 cases of allergic rhinitis in our hospital during March 2019-2020 March were selected and randomly divided into the observation group and the control group,50 cases in each group.The control group was given desloratadine treatment,and the observation group was treated with corticosteroid nasal spray combined with desloratadine.The clinical effects of the two groups were compared.Inflammatory factors and adverse reactions.Results The clinical effective rate of the observation group was 96.00%,which was significantly higher than 78.00% of the control group;After treatment,the indexes of IL-6 and IgE in the observation group were significantly lower than those in the control group,and the indexes of IgA in the observation group were significantly higher than those in the control group;The incidence of adverse reactions in the observation group was 6.00%,which was significantly lower than 22.00% in the control group (P < 0.05).Conclusion Glucocorticoid nasal spray combined with desloratadine is effective in treating allergic rhinitis in children,and it can effectively regulate inflammatory factors and reduce adverse reactions.