Bcl-2在鼻息肉中的表达、作用机制与诊疗进展

The expression,mechanism,and advances in diagnosis and therapies about Bcl-2 of nasal polyps.

鼻息肉是一种严重损害人体机能的疾病,因其显著的发病率、严重的临床症状而受到广泛的重视;。目前鼻息肉的药物治疗主要以局部应用糖皮质激素为主,手术仍然是患者管理的重要部分,但费用高、疗程久、复发率高以及长期使用鼻用糖皮质激素对鼻腔粘膜的不良影响,尤其是在哮喘与阿司匹林耐受不良的病人中,鼻息肉疾病病情的控制是一个难题。因为,对于哮喘患者,尤其是Samter三联症患者,鼻息肉复发的可能性更加明显;,使鼻息肉成为一种难以根治的疾病。现在,精准医学正在成为新的医疗趋势,虽然生物制剂等创新疗法在临床中还处于萌芽阶段,但一旦发展成熟,鼻息肉的这种新方法便意味着患者选择一个简单的办法来决定正确的治疗,并且易于实施和调整;。通过拮抗bcl-2的精准治疗,缩小鼻息肉,降低手术难度,减少长期使用激素带来的不良反应,降低鼻息肉的复发率,更好改善患者的生活质量,减轻患者的经济负担,以及减轻鼻息肉的临床症状给患者带来的负面心理情绪。对此,本文将对Bcl-2在鼻息肉中表达、作用机制及诊疗进展进行综述。

Nasal polyps is a serious debilitating disease,and it has been widely paid attention to because of its significant morbidity and severe clinical symptoms.At present,the treatment of nasal polyps are mainly composed of local application of glucocorticoids,and surgery is still an important part of patient management.But the high cost of treatment,high recurrence rate and the long-term use of nasal glucocorticoid effects of nasal mucosa,particularly in patients with asthma and aspirin intolerance,are huge challenges for controlling the disease.Because patients with asthma,especially Samter triad,have high nasal polyp recurrence,which makes nasal polyps difficult problem for human beings.Currently,precision medicine is becoming a new medical trend.Although innovative therapies such as biologics are still in their infancy in clinical practice,once developed,this new approach for nasal polyps means that patients choose a simple method to determine the correct treatment,and it is easy to implement and adjust.It can reduce the operation difficulty,reduce the bad reaction caused by long-term use of hormones,reduce the recurrence of nasal polyps,improve the quality of life of patients better,reduce the economic burden of patients,and relieve the clinical symptoms of nasal polyps bring negative psychological mood of patients.In this paper,the expression,mechanism,and advances in diagnosis and therapies about Bcl-2 of nasal polyps were reviewed.