Ang/Tie信号轴在新生血管性年龄相关性黄斑变性发病及治疗中的作用

Role of Ang/Tie signaling axis in the pathogenesis and treatment of neovascular age-related macular degeneration

血管生成素(Ang)/酪氨酸激酶受体Tie信号轴(Ang/Tie信号轴)在调节血管稳定性、血管生成以及炎症等方面发挥着重要作用。Ang1支持静止和成熟的血管表型,而Ang2常与异常的血管结构形成、血管渗漏和炎症有关。新生血管性年龄相关性黄斑变性(nAMD)是一种能导致患者出现严重视力损害的疾病,其病理特征是脉络膜新生血管的形成及炎症反应。Ang/Tie信号轴是治疗nAMD的新靶点。靶向Ang/Tie信号轴的治疗方法可促进血管稳定,抑制渗漏及炎症,与抗血管生成药物联合治疗时可产生协同作用。本文对Ang/Tie信号轴在nAMD发病及治疗中的作用进行综述,以期为nAMD的治疗提供新思路。

The angiopoietin(Ang)/tyrosine kinase receptor Tie signaling axis(Ang/Tie signaling axis)plays an important role in regulating vascular stability,angiogenesis and inflammation.Ang1 supports quiescent and mature vascular phenotype,while Ang2 is often associated with the formation of abnormal vascular structure,vascular leakage and inflammation.Neovascular age-related macular degeneration(nAMD)is a disease that can cause severe visual impairment in patients,which is pathologically characterized by the choroidal neovascularization and inflammatory reaction.Ang/Tie signaling axis is a new target for the treatment of nAMD.The therapy targeting Ang/Tie signaling axis can promote vascular stability,inhibit leakage and inflammation,and generate a synergistic effect with anti-angiogenic drugs.This article reviews the role of Ang/Tie signaling axis in the pathogenesis and treatment of nAMD,in order to provide new ideas for the treatment of nAMD.