血清淀粉样蛋白A评价强直性脊柱炎活动度的临床意义

Clinical Significance of Serum Amyloid A in Evaluating the Activity of Ankylosing Spondylitis

目的:研究血清淀粉样蛋白A(SAA)评价强直性脊柱炎(AS)活动度的临床意义。方法:对89例AS患者进行病情活动度评分(ASDAS评分),并测定SAA、C反应蛋白(CRP)、白细胞计数(WBC)、红细胞沉降率(ESR)等项目。运用非参数检验及Spearman相关性分析、ROC曲线比较AUC等方法分析SAA在评价AS活动度的临床意义。结果:SAA在正常对照组、AS非活动组及AS活动组中差异有统计学意义(χ^(2)=55.152,P<0.05);SAA对AS组最佳cut-off值为9.35 mg·L^(-1)(AUC=0.849),SAA对AS活动组最佳cut-off值为16.20 mg·L^(-1)(AUC=0.751),有明显的辅助诊断意义,差异有统计学意义(P<0.05);SAA与ASDAS评分呈显著正相关,差异有统计学意义(r=0.769,P<0.05)。结论:SAA与ASDAS评分具有相关性,初步探索证实SAA对AS以及AS活动度的诊断有一定的临床意义。

Objective:To study the clinical significance of serum amyloid A(SAA)in evaluating the activity of ankylosing spondylitis(AS).Methods:Eighty-nine patients with AS were evaluated by ASDAS.SAA,CRP,WBC and ESR were tested.The clinical significance of SAA in evaluating AS activity was analyzed by nonparametric test,Spearman correlation analysis,ROC curve and AUC.Results:There was significant difference in SAA among the normal control group,the AS inactive group and the AS active group(χ^(2)=55.152,P<0.05).The best cut-off value of SAA for the AS group was 9.35 mg·L^(-1)(AUC=0.849),and the best cut-off value of SAA for the AS activity group was 16.20 mg·L^(-1)(AUC=0.751),which had significant auxiliary diagnostic significance,and the difference was statistically significant(P<0.05).There was a significant positive correlation between SAA and ASDAS(r=0.769,P<0.05).Conclusion:There is a correlation between SAA and ASDAS.The preliminary exploration confirms that SAA has certain clinical significance in the diagnosis of AS and AS activity.