二甲双胍药动学影响因素的研究进展

Research progress of pharmacokinetic factors of metformin

二甲双胍是常见的一线口服降糖药物,但在临床使用过程中其药动学参数和药效存在较大的个体差异,需对部分患者的用药剂量进行调整以达到满意的治疗效果。影响二甲双胍药动学参数的因素众多,包括药物转运体基因多态性、药物相互作用、肠道菌群、高原低氧以及机体生理功能等。为指导二甲双胍的临床个体化用药,本研究对二甲双胍药动学影响因素的研究进展进行了综述。

Metformin is the most common first-line oral hypoglycemic drug,but there are large individual differences in pharmacokinetic parameters and pharmacodynamics during clinical use. The dosage of some patients should be adjusted to achieve satisfactory therapeutic effect. Pharmacokinetic parameters of metformin are affected by many factors, including respects of transporter gene polymorphism,drug interaction,intestinal flora,plateau hypoxia and physiological function and so on. In order to guide the clinical individualized use of metformin,this study reviews the research progress on the influencing factors of metformin pharmacokinetics.