^(18)F-FDG PET/CT脑显像联合韦氏儿童智力量表第四版评估癫痫患儿认知功能

^(18)F-FDG PET/CT brain imaging combined with Wechsler intelligence scale for children-fourth edition for evaluating cognitive function in children with epilepsy

目的观察^(18)F-FDG PET/CT脑显像联合韦氏儿童智力量表第四版(WISC-Ⅳ)评估癫痫患儿认知功能的价值。方法回顾性分析85例接受^(18)F-FDG PET/CT脑显像及WISC-Ⅳ检测的癫痫患儿资料;根据PET/CT所示脑代谢异常范围将其分为单脑叶组(n=40)和多脑叶组(n=45),并根据PET/CT示脑代谢异常灶是否位于颞叶进一步将单脑叶组患儿分为颞叶亚组(n=16)和非颞叶亚组(n=24)。比较组间及亚组间WISC-Ⅳ各项合成分数,观察病程及起病年龄与WISC-Ⅳ各项合成分数的相关性,以及单脑叶组不对称指数(AI)与年龄、起病年龄、病程及WISC-Ⅳ各项合成分数的相关性;分析^(18)F-FDG PET/CT联合WISC-Ⅳ评估癫痫患儿认知功能的价值。结果单脑叶组患儿知觉推理指数、工作记忆指数及全量表智商(IQ)均显著高于多脑叶组(P均<0.05)。颞叶亚组患儿言语理解指数低于非颞叶亚组(P<0.05)。癫痫患儿病程与言语理解指数和全量表IQ均呈负相关(r=-0.404,P<0.001;r=-0.289,P=0.007),而与知觉推理指数、工作记忆指数及加工速度指数均无明显相关性(P均>0.05);起病年龄与WISC-Ⅳ各项合成分数均无明显相关性(P均>0.05)。单脑叶组|AI|与患儿年龄、起病年龄、病程及WISC-Ⅳ各项合成分数均无明显相关性(P均>0.05)。结论^(18)F-FDG PET/CT脑显像联合WISC-Ⅳ有助于评估癫痫患儿认知功能。

Objective To observe the value of^(18)F-FDG PET/CT brain imaging combined with Wechsler intelligence scale for children-fourth edition(WISC-Ⅳ)for evaluating cognitive function in children with epilepsy.Methods Data of 85 children with epilepsy who underwent^(18)F-FDG PET/CT brain imaging and WISC-Ⅳwere retrospectively analyzed.The children were then divided into single lobe group(n=40)and multi lobe group(n=45)according to the abnormal ranges of brain metabolism shown on PET/CT,and those in single lobe group were further divided into temporal lobe subgroup(n=16)and non-temporal lobe subgroup(n=24)according to the abnormal focus of brain metabolism located in temporal lobe or not.WISC-Ⅳcomposite scores were compared between groups and subgroups,and the correlations of WISC-Ⅳcomposite scores and the course of disease,also the age of onset were observed,as well as asymmetry index(AI)and age,the age of onset,the course of disease,WISC-Ⅳcomposite scores of single lobe group.The value of^(18)F-FDG PET/CT combined with WISC-Ⅳfor evaluating cognitive function in children with epilepsy was analyzed.Results The perceptual reasoning index,working memory index and full-scale intelligence quotient(IQ)of children in single lobe group were significantly higher than those in multi lobe group(all P<0.05),and the verbal comprehension index of children in temporal lobe subgroup was lower than that in non-temporal lobe subgroup(P<0.05).The course of disease was negatively correlated with verbal comprehension index and full-scale IQ(r=-0.404,P<0.001;r=-0.289,P=0.007),but not significantly correlated with perceptual reasoning index,working memory index nor processing speed index(all P>0.05).No significant correlation was found between|AI|and the children's age,the age of onset,the course of disease nor WISC-Ⅳcomposite scores in single lobe group(all P>0.05).Conclusion^(18)F-FDG PET/CT brain imaging combined with WISC-Ⅳwas helpful for evaluating cognitive function in children with epilepsy.