一种联萘酚亚胺衍生物的荧光增强型锌离子探针

Development of a Fluorescence Enhancement Zn(Ⅲ) Sensor based on C1 Symmetric Binol Imine Derivatives

以(S)-联萘酚双醛为原料,设计合成了一个新的亚胺类席夫碱荧光探针(S)-2,在甲醇溶媒中具有较优的选择性识别Zn^(2+)的能力,与Zn^(2+)反应后可在λ=514.5 nm出现荧光的“Turn-on”现象,(S)-2对Zn^(2+)检测限可达纳摩尔级别,在30μM以下可实现定量检测,反应迅速且抗干扰能力较强。高分辨质谱提示Zn^(2+)与(S)-2发生鳌合反应生成了[Zn_(3)((S)-2)_(2)]^(2+)并引起CHEF效应,这可能是上述荧光响应的分子机制。

A novel imine Schiff base fluorescence sensor(S)-2 was designed and synthesized by using(S)-Binol-3,3’-dicarbaldehyde as initial material.(S)-2 was proved superior in selective recognizing Zn^(2+)within methanol solvent.The probe shows great fluorescence enhancement atλ=514.5 nm with presence of Zn^(2+).Quantitative test is feasible from 30μM to the detection limit which reaches nanomole level.HRMS spectroscopic indicated the formation of[Zn_(3)((S)-2)_(2)]^(2+) that lead to CHEF effect.It is considered to be probable mechanism of the fluorescence response.