天麻钩藤汤加减治疗肝阳上亢型高血压的临床应用及疗效分析

Clinical Application and Curative Effect Analysis of Modified Tianma Gouteng Decoction in the Treatment of Hypertensive Liver-yang Type Hypertension

目的探究天麻钩藤汤加减治疗原发性高血压肝阳上亢证的效果和安全性。方法回顾性分析2020年10月—2021年10月期间该院收治的90例原发性高血压肝阳上亢证患者的临床资料,以不同用药方案为分组依据,将45例采用苯磺酸左旋氨氯地平片的患者设为对照组,将其余45例加行天麻钩藤汤加减治疗的患者设为研究组。对比两组临床疗效;治疗前后的收缩压、舒张压水平;不良反应发生率;治疗前后的中医症状积分。结果研究组总有效率(97.78%)高于对照组(80.00%),差异有统计学意义(χ^(2)=7.200,P<0.05)。治疗前,研究组收缩压、舒张压分别为(165.77±14.31)、(108.19±11.48)mmHg,与对照组的(165.99±14.56)、(108.76±11.22)mmHg比较,差异无统计学意义(t=0.072、0.238,P>0.05)。治疗后,研究组收缩压、舒张压分别为(110.39±10.21)、(79.55±9.31)mmHg,低于对照组的(127.57±13.64)、(96.46±10.55)mmHg,差异有统计学意义(t=6.764、8.062,P<0.05)。研究组不良反应发生率(2.22%)与对照组(8.88%)比较,差异无统计学意义(χ^(2)=0.847,P>0.05)。治疗前,研究组中医症状积分为(22.23±5.24)分,与对照组的(22.67±5.58)分比较,差异无统计学意义(t=0.386,P>0.05);治疗后,研究组中医症状积分为(5.77±2.21)分,低于对照组的(14.23±4.24)分,差异有统计学意义(t=11.869,P<0.05)。结论天麻钩藤汤加减治疗原发性高血压肝阳上亢证的安全性和有效性显著,血压水平得到有效控制,中医症状也显著改善。

Objective To explore the effect and safety of Tianma Gouteng decoction in the treatment of primary hypertension with liver-yang hyperactivity syndrome.Methods A retrospective analysis of the clinical data of 90 patients with primary hyperten⁃sion with liver-yang hyperactivity syndrome admitted to the hospital from October 2020 to October 2021.Based on the different medication regimens adopted,45 patients who received levamlodipine besylate tablets were set as the control group,and the re⁃maining 45 patients who received Tianma Gouteng decoction were set as the study group.Clinical efficacy;systolic and dia⁃stolic blood pressure levels before and after treatment;incidence of adverse reactions;TCM symptom scores before and after treatment were compared.Results The total effective rate in the study group(97.78%)was higher than that in the control group(80.00%),and the difference was statistically significant(χ^(2)=7.200,P<0.05).Before treatment,the systolic blood pressure and diastolic blood pressure in the study group were(165.77±14.31)mmHg and(108.19±11.48)mmHg,respectively,compared with(165.99±14.56)mmHg and(108.76±11.22)mmHg in the control group,the difference was not statistically significant(t=0.072,0.238,P>0.05).After treatment,the systolic blood pressure and diastolic blood pressure in the study group were(110.39±10.21)mmHg and(79.55±9.31)mmHg,respectively,which were lower than those in the control group(127.57±13.64)mmHg and(96.46±10.55)mmHg,and the difference was statistically significant(t=6.764,8.062,P<0.05).There was no statistically sig⁃nificant difference in the incidence of adverse reactions in the study group(2.22%)and the control group(8.88%)(χ^(2)=0.847,P>0.05).Before treatment,the TCM symptom score of the study group was(22.23±5.24)points,compared with(22.67±5.58)points of the control group,the difference was not statistically significant(t=0.386,P>0.05);after treatment,the TCM symptoms score of the study group was(5.77±2.21)points,which was lower than that of the control group(14.23±4.24)points,and the difference was statistically significant(t=11.869,P<0.05).Conclusion Tianma Gouteng decoction is safe and effective in the treatment of primary hypertension with liver-yang hyperactivity syndrome.Not only the blood pressure level is effectively controlled,but the symptoms of traditional Chinese medicine are also significantly improved.