缩宫素联合卡前列素氨丁三醇、米索对胎盘早剥产后大出血患者的应用效果探讨

Discussion on the Application Effect of Oxytocin Combined with Carbo⁃prost Tromethamine and Miso in Patients with Postpartum Hemorrhage af⁃ter Placental Abruption

目的探究缩宫素联合卡前列素氨丁三醇、米索对胎盘早剥产后大出血产妇的应用效果。方法便利抽取该院2016年1月—2021年1月收治的胎盘早剥产后大出血产妇100例为研究对象,采用随机数字表法将其分为对照组和观察组,每组50例,对照组采用缩宫素和米索治疗,观察组在对照组的基础上增加卡前列素氨丁三醇治疗,比较两组产妇药物治疗疗效、持续出血时间、止血时间、住院时间,不同手术时间段内产妇出血量,用药前后的生命体征及用药后不良反应。结果观察组产妇用药后治疗总有效率(86%)高于对照组(64%),差异有统计学意义(χ^(2)=6.453,P<0.05);用药后,观察组术后10 min、60 min、2 h、24 h出血量均低于同时期对照组术后出血量,差异有统计学意义(t=24.030、33.130、36.610、39.340,P<0.05),且观察组产妇持续出血时间、止血时间及住院时间均短于对照组,差异有统计学意义(t=7.762、7.469、10.590,P<0.05);两组产妇用药前、用药30 min后同时期生命体征比较,差异无统计学意义(t=0.455、0.583、0.203、1.423、1.941、0.804,P>0.05);两组产妇用药后不良反应总发生率比较,差异无统计学意义(χ^(2)=0.298,P>0.05)。结论缩宫素联合卡前列素氨丁三醇、米索可以提升胎盘早剥产后大出血产妇的临床治疗有效率,降低患者出血量,缩短患者治疗时间。

Objective To explore the application effect of oxytocin combined with carboprost tromethamine and miso on postpar⁃tum hemorrhage after placental abruption.Methods A total of 100 puerperae with postpartum hemorrhage after placental abrup⁃tion who were admitted to the hospital from January 2016 to January 2021 were conveniently selected as the research objects.All puerperae were divided into a control group and an observation group by random number table method,with 50 cases in each group.The control group was treated with oxytocin and miso,and the observation group was additionally treated with car⁃boprost tromethamine on the basis of the control group,and compared the two groups of maternal drug treatment efficacy,con⁃tinuous bleeding time,hemostasis time,hospitalization time,maternal blood loss in different operation time periods,vital signs before and after medication,and adverse reactions after medication.Results The total effective rate of the observation group af⁃ter medication was 86%higher than that of the control group 64%,and the difference was statistically significant(χ^(2)=6.453,P<0.05).After medication,the bleeding volume of the observation group at 10 min,60 min,2 h,and 24 h after surgery was lower than that of the control group at the same period,and the difference was statistically significant(t=24.030,33.130,36.610,39.340,P<0.05),and the continuous bleeding time,hemostasis time and hospitalization time of puerperae in the observation group were all shorter than that of the control group,the difference was statistically significant(t=7.762,7.469,10.590,P<0.05);there was no statistically significant difference in the vital signs between the two groups before and 30 minutes after the medication(t=0.455,0.583,0.203,1.423,1.941,0.804,P>0.05);there was no statistically significant difference in the total in⁃cidence of adverse reactions between the two groups after medication(χ^(2)=0.298,P>0.05).Conclusion Oxytocin combined with carboprost tromethamine and miso can improve the clinical treatment efficiency of postpartum hemorrhage after placental abrup⁃tion,reduce the amount of bleeding,and shorten the treatment time.