基质金属蛋白酶对种植体周围炎影响的研究进展

Research progress in the effect of matrix metalloproteinase on peri-implantitis

种植体周围炎是口腔种植失败的重要原因,目前尚缺乏有效的预防及治疗措施。近年来,基质金属蛋白酶(MMPs)作为重要的生物标志物之一,在牙周病、糖尿病、心血管疾病及癌症中研究广泛。通过对MMPs分子检测及靶向药物治疗的深入研究,种植体周围宿主反应特征的科学证据逐渐为种植体周围病变提供更广泛、准确的诊断和治疗窗口。本文就MMPs在种植体周围炎发病机制、诊断及治疗等方面的作用进行总结,为MMPs在种植体周围炎中的运用提供理论依据。

Periimplantitis is an important cause of oral implant failure,but there are still no effective prevention and treatment measures.In recent years,matrix metalloproteinases(MMPs),as one of the important biological markers,has been extensively studied in periodontal disease,diabetes,cardiovascular disease and cancer research.Through the in-depth study of MMPs molecular detection and targeted drug therapy,scientific evidences regarding the host response characteristics around the implant gradually provide more extensive and accurate diagnosis and treatment guidance forlesions around implant.This paper summarizes the role of MMPs in the pathogenesis,diagnosis and treatment of peri-implantitis,and provides theoretical basis for the application of MMPs in peri-implantitis.