白介素6基因多态性与多种疾病的相关性研究

Correlation Between Interleukin 6 Gene Polymorphism and Various Diseases

白细胞介素6(IL-6)是一种多效细胞因子,不仅具有免疫学作用,而且还具有造血、骨骼代谢和组织再生等功能。炎性细胞因子IL-6基因多态性可通过影响机体自身和其他细胞因子的转录和表达,在临床多种疾病中发挥重要的影响作用。因此,IL-6基因多态性研究成为心脑血管、血栓、肝病、风湿免疫、癌症等多种疾病的研究热点。本文对IL-6的基因多态性与多种疾病相关性的研究进展进行综述,以期为临床治疗相关疾病提供理论依据。

Interleukin-6(IL-6) is a multi-effect cytokine,which not only has immunological function,but also has hematopoietic,bone metabolism and tissue regeneration functions.IL-6 gene polymorphism of inflammatory cytokines can play an important role in clinical diseases by affecting the transcription and expression of the body itself and other cytokines.Therefore,the study of IL-6 gene polymorphism has become a research hotspot in cardiovascular and cerebrovascular diseases,thrombosis,liver diseases,rheumatic immunity,cancer and other diseases.This paper reviews the research progress on the correlation between IL-6 gene polymorphism and various diseases,in order to provide theoretical basis for clinical treatment of related diseases.