穴位埋线配合运中定坤汤治疗早发性卵巢功能不全疗效观察

Efficacy Observation of Acupoint Thread Embedding Combined with Yun Zhong Ding Kun Tang for Premature Ovarian Insufficiency

目的观察穴位埋线配合运中定坤汤治疗早发性卵巢功能不全的临床疗效及其对下丘脑-垂体-卵巢轴功能的影响。方法将80例早发性卵巢功能不全患者随机分为治疗组和对照组,每组40例。对照组采用运中定坤汤内服治疗,治疗组在对照组基础上配合穴位埋线治疗。治疗3个月经周期后,观察两组治疗前后各项症状(月经周期紊乱、月经量减少或闭经、潮热汗出、腰膝酸软、易怒心烦)积分、症状自评量表(SCL-90)积分、超声检测指标[卵巢直径(OVD)、窦卵泡数(AFC)、卵巢基质血流阻力指数(RI)]及血清内分泌激素[促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E_(2))、抗缪勒管激素(AMH)]水平的改善情况,并比较两组临床疗效。结果治疗组总有效率为89.8%,明显高于对照组的68.4%,两组比较差异具有统计学意义(P<0.05)。两组治疗后各项症状积分、SCL-90积分、超声检测指标、血清内分泌激素水平与同组治疗前比较,差异均具有统计学意义(P<0.05)。治疗组治疗后各项症状积分、SCL-90积分、超声检测指标、血清内分泌激素水平与对照组比较,差异均具有统计学意义(P<0.05)。结论穴位埋线配合运中定坤汤能调节早发性卵巢功能不全患者下丘脑-垂体-卵巢轴功能,纠正内分泌功能失调,有助于改善患者卵巢功能,缓解临床症状。

Objective To observe the clinical efficacy of acupoint thread embedding plus Yun Zhong Ding Kun Tang in treating premature ovarian insufficiency(POI)and its impact on the hypothalamus-pituitary-ovarian axis function.Method Eighty POI patients were randomized into a treatment group and a control group,with 40 cases in each group.The control group received oral administration of Yun Zhong Ding Kun Tang for treatment,based on which the treatment group received additional acupoint thread embedding.After treatment for three menstrual cycles,the improvements in the symptom scores(menstrual cycle disorder,decreased menstrual volume or amenorrhea,flush and perspiration,weakness in the low back and knees,vexation and irritability),symptom checklist 90(SCL-90)score,ultrasound parameters[ovary diameter(OVA),antral follicle counting(AFC),and resistance index(RI)of the ovarian stromal blood flow],and serum endocrine hormone levels[follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),and anti-mullerian hormone(AMH)]were observed,and the clinical efficacy was compared between the two groups.Result The total effective rate was 89.8%in the treatment group,significantly higher than 68.4%in the control group,and the between-group difference was statistically significant(P<0.05).The symptom scores,SCL-90 score,ultrasound parameters,and serum endocrine hormone levels changed significantly after treatment in both groups compared with the baseline(P<0.05).After treatment,the symptom scores,SCL-90 score,ultrasound parameters,and serum endocrine hormone levels in the treatment group were significantly different from those in the control group(P<0.05).Conclusion Acupoint thread embedding plus Yun Zhong Ding Kun Tang can regulate the hypothalamus-pituitary-ovarian axis function and correct the endocrine dysfunction in POI patients to help improve ovarian function and relieve clinical symptoms.