中药抗抑郁有效成分及其作用机制研究进展

Research progress on effective components and mechanisms of anti-depressive Chinese medicine

抑郁症发病机制复杂,西药治疗效果不佳且副作用大,中药辨证论治优势独特,其中抗抑郁的主要有效成分包括黄酮类、萜类、苯丙素类、醌类和生物碱类等多种化学成分,这些化学成分通过调节单胺类神经递质类生化异常和脑组织蛋白含量、机体内环境及能量代谢功能等多方面作用,发挥延缓病程、提高西药疗效并降低副作用等作用,使中药治疗得到越来越多的关注和认可。该文系统综述了中药抗抑郁有效成分及其作用机制,为抗抑郁中药新药的合理开发和利用提供指导。

Since the pathogenesis of depression is complicated,the therapeutic effects of western medicine are poor accompanied by severe side effects.Chinese medicine has unique advantages in the treatment based on syndrome differentiation and contains many effective components against depression,including flavonoids,terpenes,phenylpropanoids,quinones,and alkaloids.These chemical components can delay the course of the disease,improve the curative effect,and reduce side effects of western medicine by regulating the biochemical abnormalities of monoamine neurotransmitters,brain tissue protein content,and internal environment as well as energy metabolism to make the treatment of Chinese medicine highlighted and recognized.This study systematically reviewed the effective components and mechanisms of anti-depressive Chinese medicine to inspire the rational development and utilization of new Chinese medicines against depression.