酒萸肉环烯醚萜类化学成分研究

Iridoids of wine-processed Corni Fructus

综合运用各种柱色谱分离技术对酒萸肉的化学成分进行研究,并应用现代波谱技术对分离得到的化合物进行结构鉴定。从酒萸肉的水提取物中分离得到10个环烯醚萜类化合物,分别为7β-O-(2″-formylfuran-5″-methylene)-morroniside(1)、7-脱氢马钱子苷(7-dehydrologanin,2)、獐牙菜苷(sweroside,3)、7β-O-甲氧基莫诺苷(7β-O-methylmorroniside,4)、7α-O-甲氧基莫诺苷(7α-O-methymorroniside,5)、7β-O-乙氧基莫诺苷(7β-O-ethylmorroniside,6)、7α-O-乙氧基莫诺苷(7α-O-ethylmorroniside,7)、山茱萸新苷(cornuside,8)、脱水莫诺苷元(sarracenin,9)、马钱苷(loganin,10)。其中化合物1为新化合物,命名为cornushmf A。

A new iridoid glycoside,cornushmf A(1)and nine known iridoids(2-10)were isolated from the water extract of the wine-processed Corni Fructus by various column chromatographies.Their chemical structures were identified by comprehensive spectroscopic methods as 7β-O-(2″-formylfuran-5″-methylene)-morroniside(1),7-dehydrologanin(2),sweroside(3),7β-O-methylmorroniside(4),7α-O-methylmorroniside(5),7β-O-ethylmorroniside(6),7α-O-ethylmorroniside(7),cornuside(8),sarracenin(9),and loganin(10).