雷公藤毒性研究进展的CiteSpace知识图谱分析

CiteSpace knowledge map analysis of research progress on Tripterygium wilfordii toxicity

该研究检索了中国知网(CNKI)及Web of Science(WoS)自建库至2021年8月31日已发表的雷公藤毒性相关的国内外文献,运用文献计量学及CiteSpace 5.8.3软件对研究作者、研究机构及关键词等内容进行可视化展示,并结合信息提取方法对雷公藤安全性研究的现状及发展趋势进行分析,以发现研究热点、演化路径及发展趋势,为今后研究提供铺垫与参考。经过筛选最终纳入中文文献1876篇,英文文献243篇。结果表明,汪祺、ZHANG Luyong分别是发表中文和英文文献量最多的作者;而中国食品药品检定研究院、中国药科大学分别是发表中文和英文文献量最多的研究机构,机构间合作较少;中、英文文献关键词分析显示雷公藤安全性研究主要集中在临床监测、作用机制、剂型改善、质量标准、成分分析、单体研究、增效减毒等方面,代谢组学、雷公藤红素及毒性机制是以后的研究热点。目前雷公藤毒性相关的研究仍处于发展阶段,需注重研究的深入并加强作者或机构的跨团体、跨区域的合作强度,为雷公藤毒性的相关研究提供参考。

This study systematically searched CNKI and Web of Science(WoS)for the research papers on the toxicity of Tripterygium wilfordii included from database inception to August 31,2021,and visually displayed the authors,research institutions,keywords,and other contents using bibliometrics and CiteSpace 5.8.3.Furthermore,the current situation and research progress on T.wilfordii safety were also analyzed based on information extraction to find the research hotspot,evolution path,and development trend,and to provide references for future research.A total of 1876 Chinese papers and 243 English papers were included in the study.The analysis of authors showed that WANG Qi and ZHANG Luyong had the most publications in Chinese and English papers,respectively.According to the analysis of research institutions,National Institutes for Food and Drug Control and China Pharmaceutical University possessed the largest number of Chinese and English papers,respectively,but there was less cooperation between them.The analysis of keywords in Chinese and English papers showed that the research contents of the safety of T.wilfordii mainly focused on clinical monitoring,mechanism,dosage form improvement,quality standard,component analysis,monomer research,efficiency and toxicity reduction,etc.Metabonomics,tripterine,and the underlying mechanism of toxicity were the research hotspots in the future.At present,the research on the toxicity of T.wilfordii is still under development.It is necessary to highlight the in-depth research and strengthen the inter-group and inter-region cooperation of authors or institutions to provide references for the research on the toxicity of T.wilfordii.