基于药性表征思路的中药挥发油经皮外用“药辅兼济”研究模式

Research model integrating"both medicinal and adjuvant properties"for essential oils from Chinese medicinal:based on characterization of medicinal properties

中药挥发油具有“药”“辅”双重作用并可以直接组方入药,传统效应研究思路是比较加入挥发油前后复方效应变化但不能阐明促渗作用,现代研究则套用化学促渗剂思路研究透皮促渗作用而忽视了其整体效应。该文在证明中药挥发油透皮促渗作用存在药性规律的基础上,基于“组分-递送-效应”外用中药药性表征思路,探索性地提出中药挥发油经皮外用“药辅兼济”研究模式,其核心思想是认为中药挥发油多元组分及其不同递送过程是决定其外用效应的关键因素,该研究模式有望为在中医原创思维指导下开展中药挥发油经皮外用研究提供借鉴。

Essential oils(EOs)from Chinese medicinals,which can be used as adjuvants and exert certain therapeutic effect,are directly used in Chinese medicine formulas.Conventional research strategy for EOs from Chinese medicinals is to compare the efficacy of the prescriptions before and after the addition of EOs,and the penetration-enhancing mechanisms of EOs remain unclear.In modern research on EOs from Chinese medicinals,the method for studying chemical penetration enhancers is often used,which fails to reflect the overall efficacy of EOs.This study clarified the property regularity of EOs from Chinese medicinals as transdermal penetration enhancers,and thereby proposed a research model which integrated the medicinal and adjuvant properties of EOs from Chinese medicinals via"component-delivery-effect"characterization route.The core concept is that constituents of EOs from Chinese medicinals and their delivery process play a key role in their external application.This research model is expected to serve as a reference for further research on EOs from Chinese medicinals for transdermal application.