苯磺酸左氨氯地平治疗冠心病合并轻中度高血压患者的效果及其对动态血压的影响

Effect of Levamlodipine Besylate in the Treatment of Patients with Coronary Heart Disease Complicated with Mild to Moderate Hypertension and Its Influence on Ambulatory Blood Pressure

目的:观察苯磺酸左氨氯地平治疗冠心病合并轻中度高血压患者的效果及其对动态血压的影响。方法:选取北京市朝阳区双桥医院2019年6月-2021年6月收治的冠心病合并轻中度高血压患者98例。根据数字表随机法将其分成研究组和对照组,各49例。两组均给予冠心病的常规治疗,在此基础上,对照组给予硝苯地平缓释片,研究组给予苯磺酸左氨氯地平片。比较两组临床疗效,治疗前,以及治疗2、4、6、8周后的收缩压及舒张压,舒张压和收缩压降压谷峰值比率及不良反应。结果:对照组总有效率为79.59%,研究组总有效率为87.76%,两组治疗总有效率比较差异无统计学意义(P>0.05)。两组治疗前,治疗2、4、6、8周后的收缩压和舒张压比较差异均无统计学意义(P>0.05),两组治疗2、4、6、8周后的收缩压和舒张压均低于治疗前(P<0.05)。研究组收缩压及舒张压的降压谷峰值比率均高于对照组(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论:对于冠心病合并轻中度高血压患者而言,在冠心病常规治疗基础上应用苯磺酸左氨氯地平治疗可更稳定持续有效地控制患者的血压水平,减少药物不良反应,总体效果优于硝苯地平。

Objective:To observe the effect of Levamlodipine Besylate in the treatment of patients with coronary heart disease complicated with mild to moderate hypertension and its influence on ambulatory blood pressure.Method:A total of 98 patients with coronary heart disease complicated with mild to moderate hypertension treated in Chaoyang District Shuangqiao Hospital of Beijing from June 2019 to June 2021 were selected.They were divided into study group and control group according to random number table method,with 49 cases in each group.Both groups were given routine treatment of coronary heart disease.On this basis,the control group was given Nifedipine Sustained-Release Tablets,and the study group was given Levamlodipine Besylate Tablets.The clinical efficacy,systolic blood pressure and diastolic blood pressure before treatment,after 2,4,6 and 8 weeks of treatment,depressurization valley peak ratio of diastolic blood pressure and systolic blood pressure and adverse reactions were compared between the two groups.Result:The total effective rate was 79.59% in the control group and 87.76% in the study group.There was no significant difference in the treatment total effective rate between the two groups(P>0.05).Before treatment,after 2,4,6 and 8 weeks of treatment,there were no significant differences in systolic blood pressure and diastolic blood pressure in the two groups(P>0.05),and the systolic blood pressure and diastolic blood pressure of the two groups after 2,4,6 and 8 weeks of treatment were lower than those before treatment(P<0.05).The depressurization valley peak ratioes of systolic and diastolic blood pressure in the study group were higher than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion:For patients with coronary heart disease complicated with mild to moderate hypertension,the application of Levamlodipine Besylate on the basis of routine treatment of coronary heart disease can more stably,continuously and effectively control the blood pressure level of patients and reduce drug adverse reactions.The overall effect is better than Nifedipine.