苯扎氯铵阴道冲洗在子宫颈癌同步放化疗患者中的应用

Application of Benzalkonium Chloride Vaginal Irrigation in Patients with Concurrent Chemoradiotherapy for Cervical Cancer

目的:探讨苯扎氯铵阴道冲洗在子宫颈癌同步放化疗患者中的应用。方法:选取福建医科大学附属第二医院肿瘤放射治疗科2019年1月-2021年7月收治的89例接受根治性同步放化疗的子宫颈癌患者作为研究对象。随机将其分为观察组(45例)和对照组(44例)。对照组采用普通温水阴道冲洗,观察组采用苯扎氯铵阴道冲洗。比较两组临床疗效,放化疗期间放射性尿道炎、阴道炎发生率。结果:两组均无病情进展(PD)病例,观察组总有效率为97.78%,对照组为95.45%,两组总有效率比较差异无统计学意义(P>0.05)。观察组放射性尿道炎6例,其中2例合并细菌感染,对照组放射性尿道炎14例,其中合并细菌感染10例;观察组放射性尿道炎发生率低于对照组(P<0.05)。观察组放射性阴道炎7例,其中2例合并细菌感染,对照组放射性阴道炎16例,其中11例合并细菌感染,观察组放射性阴道炎发生率低于对照组(P<0.05)。结论:与普通温水阴道冲洗相比,采用苯扎氯铵稀释液阴道冲洗不会降低疗效,但可以有效降低子宫颈癌同步放化疗放射性阴道炎、尿道炎的发生率,对维持阴道卫生具有良好的作用。

Objective:To investigate the application of Benzalkonium Chloride vaginal irrigation in patients with concurrent chemoradiotherapy for cervical cancer.Method:A total of 89 patients with cervical cancer who received radical concurrent chemoradiotherapy in the department of tumor radiotherapy of the Second Affiliated Hospital of Fujian Medical University from January 2019 to July 2021 were selected as the research objects.They were randomly divided into observation group(45 cases)and control group(44 cases).The control group was treated with ordinary warm water vaginal irrigation,and the observation group was treated with Benzalkonium Chloride vaginal irrigation.The clinical efficacy and the incidences of radioactive urethritis and vaginitis during chemoradiotherapy were compared between the two groups.Result:There were no cases of progressive disease(PD)in the two groups.The total effective rate was 97.78% in the observation group and 95.45% in the control group.There was no significant difference in the total effective rate between the two groups(P>0.05).There were 6 cases of radioactive urethritis in the observation group,including 2 cases with bacterial infection,and 14 cases of radioactive urethritis in the control group,including 10 cases with bacterial infection;the incidence of radioactive urethritis in the observation group was lower than that in the control group(P<0.05).There were 7 cases of radioactive vaginitis in the observation group,of which 2 cases were complicated with bacterial infection,and 16 cases of radioactive vaginitis in the control group,of which 11 cases were complicated with bacterial infection.The incidence of radioactive vaginitis in the observation group was lower than that in the control group(P<0.05).Conclusion:Compared with ordinary warm water vaginal irrigation,vaginal irrigation with Benzalkonium Chloride diluent will not reduce the curative effect,but it can effectively reduce the incidences of radioactive vaginitis and urethritis of cervical cancer concurrent chemoradiotherapy,and it has a good effect on maintaining vaginal hygiene.