坎地沙坦酯辅助治疗对老年肺心病急性期合并呼吸衰竭患者的影响

Effect of Candesartan Cilexetil Adjuvant Therapy on Elderly Patients with Acute Cor Pulmonale Complicated with Respiratory Failure

目的:探讨坎地沙坦酯辅助治疗对老年肺心病急性期合并呼吸衰竭患者的影响。方法:选取吴川市人民医院2019年3月-2021年6月收治的73例老年肺心病急性期合并呼吸衰竭患者作为研究对象。按照随机数字表法将其分为对照组(n=36)和观察组(n=37)。两组均予以基础治疗,对照组给予无创呼吸机治疗,观察组在对照组基础上给予坎地沙坦酯片治疗。比较两组临床疗效、治疗前后心肺功能、血清生物学指标及血气指标。结果:观察组总有效率(89.19%)高于对照组(69.44%),差异有统计学意义(P<0.05)。治疗后,观察组呼气流量峰值(PEF)、每搏输出量(SV)均高于对照组,肺动脉压(PAP)低于对照组(P<0.05)。治疗后,观察组内皮素-1(ET-1)、Clara细胞蛋白16(CC16)及和肽素(Copeptin)水平均低于对照组(P<0.05)。治疗后,观察组动脉氧分压(PaO_(2))高于对照组,二氧化碳分压(PaCO_(2))低于对照组(P<0.05)。结论:坎地沙坦酯辅助治疗通过调节老年肺心病急性期合并呼吸衰竭患者血液中的氧气和二氧化碳比例,改善血气情况,提高心肺功能,从而降低ET-1、CC16及Copeptin水平,恢复内皮功能,疗效显著。

Objective:To investigate the effect of Candesartan Cilexetil adjuvant therapy on elderly patients with acute cor pulmonale complicated with respiratory failure.Method:A total of 73 elderly patients with acute cor pulmonale complicated with respiratory failure admitted to Wuchuan People’s Hospital from March 2019 to June 2021 were selected as the research objects.They were divided into control group(n=36)and observation group(n=37)according to the random number table method.Both groups were treated with basic treatment,the control group was treated with noninvasive ventilator,and the observation group was treated with Candesartan Cilexetil Tablets on the basis of the control group.The clinical efficacy,cardiopulmonary function,serum biological indexes and blood gas indexes before and after treatment of the two groups were compared.Result:The total effective rate of the observation group(89.19%)was higher than that of the control group(69.44%),the difference was significant(P<0.05).After treatment,the peak expiratory flow(PEF)and stroke volume(SV)in the observation group were higher than those in the control group,and the pulmonary artery pressure(PAP)was lower than that in the control group(P<0.05).After treatment,the levels of endothelin-1(ET-1),Clara cell protein 16(CC16)and Copeptin in the observation group were lower than those in the control group(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO_(2))in the observation group was higher than that in the control group,and the partial pressure of carbon dioxide(PaCO_(2))was lower than that in the control group(P<0.05).Conclusion:Candesartan Cilexetil adjuvant therapy can improve blood gas condition and cardiopulmonary function by regulating the proportion of oxygen and carbon dioxide in the blood of elderly patients with acute cor pulmonale complicated with respiratory failure,so as to reduce the levels of ET-1,CC16 and Copeptin and restore endothelial function,with significant efficacy.