腹腔镜手术对子宫内膜异位症患者炎症因子、氧化应激的影响

Effects of Laparoscopic Surgery on Inflammatory Factors and Oxidative Stress in Patients with Endometriosis

目的:探讨腹腔镜手术对子宫内膜异位症患者炎症因子、氧化应激的影响。方法:选取浠水县妇幼保健院2019年5月-2020年5月收治的80例子宫内膜异位症患者,按随机数字表法分为对照组和观察组,各40例,给予对照组传统开腹手术,给予观察组腹腔镜手术,比较两组临床疗效、炎症因子、氧化应激、凝血功能指标。结果:观察组总有效率高于对照组(P<0.05),组间术后即刻与麻醉前D-二聚体(D-D)比较差异无统计学意义(P>0.05),组间术后3 d的D-D高于麻醉前(P<0.05),术后即刻和术后3 d观察组血小板计数(PLT)高于对照组,凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)短于对照组(P<0.05);与术前相比,术后两组患者白介素-6(IL-6)、白介素-8(IL-8)、C反应蛋白(CRP)水平均有所提高,但观察组低于对照组(P<0.05),术前两组氧化应激反应水平比较差异无统计学意义(P>0.05),术后两组活性氧(ROS)、丙二醇(MDA)和晚期氧化蛋白产物(AOPP)水平均有所提高,但观察组低于对照组(P<0.05)。结论:腹腔镜手术可有效改善子宫内膜异位症患者凝血功能,降低机体炎症反应和氧化应激反应,临床效果显著。

Objective:To investigate the effect of laparoscopic surgery on inflammatory factors,oxidative stress in patients with endometriosis.Method:A total of 80 patients with endometriosis who treated in Xishui Maternal and Child Health Hospital from May 2019 to May 2020 were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was given traditional laparotomy and the observation group was given laparoscopic surgery.The clinical efficacy,inflammatory factors,oxidative stress and coagulation function indexes of the two groups were compared.Result:The total effect rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in D-Dimer(D-D)between immediately after operation and before anesthesia in two groups(P>0.05).3 days after operation,the D-D was higher than that before anesthesia in two groups(P<0.05).After operation and 3 days after operation,the platelet count(PLT)of the observation group was higher than that of the control group,and the thrombin time(TT),prothrombin time(PT)and activated partial thrombin time(APTT)of the observation group were shorter than those of the control group(P<0.05).Compared with before operation,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and C-reactive protein(CRP)in the two groups were increased,but the levels in the observation group were lower than those in the control group(P<0.05).There were no significant differences in the level of oxidative stress reaction between the two groups before operation(P>0.05).The levels of reactive oxygen species(ROS),malondialdehyde(MDA)and advanced oxidation protein product(AOPP)in the two groups were higher after operation,but those in the observation group were lower than those in the control group(P<0.05).Conclusion:Laparoscopic surgery can effectively improve the coagulation function of patients with endometriosis and reduce the inflammatory response and oxidative stress response.The clinical effect is remarkable.