弥漫大B细胞淋巴瘤的DNA甲基化改变及治疗进展

Research progress of DNA methylation in diffuse large B-cell lymphoma

弥漫大B细胞淋巴瘤(DLBCL)异质性较高,具有不同的临床和病理特征,是成人淋巴瘤的一种常见类型。尽管一部分DLBCL已经可以治愈,但难治和复发患者的治疗仍然具有挑战性。近年来,DNA甲基化等表观遗传修饰成为DLBCL的研究热点。调控甲基化修饰的基因突变及抑癌基因甲基化修饰在DLBCL发病及预后中起到关键作用。本文对DLBCL的DNA甲基化研究进展进行综述。

Diffuse large B-cell lymphoma(DLBCL)is a common type of adult lymphoma with high heterogeneity and different clinical and pathological features.Although some DLBCLs are curable,the management of refractory and relapsed patients remains challenging.In recent years,epigenetic modifications such as DNA methylation have become a research hotspot of DLBCL.Gene mutations regulating methylation modification and methylation modification of tumor suppressor genes play a key role in the pathogenesis and prognosis of DLBCL.This paper reviews the research progress of DNA methylation in DLBCL.