粪菌移植在新生儿坏死性小肠结肠炎中的研究进展

Progress in fecal microbiota transplantation in neonatal necrotizing enterocolitis

新生儿坏死性小肠结肠炎是新生儿特别是早产儿疾病和死亡的主要原因之一,其发病机制与肠道微生物异常密切相关。近年来,粪菌移植除了在成人及儿童胃肠道疾病及胃肠道外疾病的应用日益广泛外,其在新生儿坏死性小肠结肠炎动物模型中也有大量研究。本文就粪菌移植在新生儿坏死性小肠结肠炎治疗中的可能作用机制以及研究进展进行综述。

Neonatal necrotizing enterocolitis(NEC)is one of the leading causes of morbidity and mortality in newborns,especially in premature infants.The pathogenesis of NEC is closely related to intestinal microbiota disorders.In recent years,fecal microbiota transplantation(FMT)has been widely used in the treatment of gastrointestinal diseases and extra-gastrointestinal diseases in adults and children.A large number of studies have also been conducted in NEC animal models.This article reviews the possible mechanism of FMT in the treatment of NEC and the progress in this respect.