小儿MPP合并EB病毒感染的临床表现及危险因素Logistic回归分析

Clinical manifestations of children with MPP and EB virus infection and Logistic regression analysis of risk factors

目的 探讨小儿肺炎支原体肺炎(MPP)合并EB病毒感染的临床表现并分析其危险因素。方法 选取164例MPP合并EB病毒感染的患儿作为研究组,95例单纯EB病毒感染的上呼吸道感染患儿作为对照组,收集所有患儿的一般资料、临床特征,进行Logistic回归分析危险因素。结果 两组患儿在年龄、发病季节、出生低体质量、流行接触史、免疫力低下、高热、呼吸困难、发热时间≥10天、肺部阴影≥2/3肺叶、胸腔积液、血沉≥50 mm/h、C反应蛋白≥8 mg/L上的差异有统计学意义(P<0.05);余指标差异无显著性。Logistic回归分析显示流行接触史(OR=2.438)、免疫力低下(OR=3.808)、发热时间≥10天(OR=2.000)、肺部阴影≥2/3肺叶(OR=1.772)、血沉≥50 mm/h(OR=3.062)、C反应蛋白≥8 mg/L(OR=2.192)是MPP合并EB病毒感染的危险因素。结论 小儿MPP合并EB病毒感染有明显的临床表现及流行病学特征,降低高危因素有助于MPP合并EB病毒感染的防治。

Aim To explore the clinical manifestations of children with Mycoplasma pneumoniae pneumonia(MPP) and EB virus infection and analyze the risk factors. Methods A total of 164 children with MPP and EB virus infection(study group) and 95 children with upper respiratory tract infection infected with simple EB virus were used as the control group. The general data and clinical characteristics of all children were collected. Logistic regression analysis was conducted to analyze the risk factors. Results There were significant differences in age, onset season, low birth weight, epidemic exposure history, low immunity, hyperpyrexia, dyspnea, fever time not shorter than 10 d, lung shadow not smaller than 2/3 lung lobe, pleural effusion, erythrocyte sedimentation rate not lower than 50 mm/h and C-reactive protein not lower than 8 mg/L between the two groups(P<0.05), while there were no significant difference in gender, cesarean section, vomiting, lymphadenopathy and rash. Logistic regression analysis showed that epidemic exposure history(OR=2.438), low immunity(OR=3.808), fever time not shorter than 10 day(OR=2.000), lung shadow not smaller than 2/3 lung lobe(OR=1.772), erythrocyte sedimentation rate not lower than 50 mm/h(OR=3.062) and C-reactive protein not lower than 8 mg/L(OR=2.192) were the risk factors of MPP combined with EB virus infection. Conclusions There are significant clinical manifestations and epidemiological characteristics in children with MPP and EB virus infection. Reducing high-risk factors is conductive to the prevention of MPP combined with EB virus infection.