慢性肾脏病高磷血症的研究进展

Research updates on hyperphosphatemia in Chronic kidney disease

慢性肾脏病(chronic kidney disease,CKD)患病率高,随肾功能下降,磷代谢异常逐渐加重。我国CKD伴高磷血症呈患病率高、达标率低的特点。高磷血症是慢性肾脏病患者肾病进展、继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT)、心血管事件和全因死亡的独立危险因素。本文综述了慢性肾脏病时高磷血症的调控机制及其不良预后的机制。

Chronic kidney disease(CKD)is highly prevalent in general population.With the decline of kidney function,the abnormality of phosphorus metabolism is gradually aggravated.In China,hyperphosphatemia in CKD is characterized by high prevalence and low control rate.Hyperphosphatemia is an independent risk factor of CKD progression,secondary hyperparathyroidism,cardiovascular events,and all-cause mortality in CKD patients.Literatures on mechanisms of hyperphosphatemia and its adverse outcomes were reviewed.