可穿戴透析设备尿素去除技术进展

Progress in urea removal technology of wearable dialysis equipment

可穿戴人工肾(wearable artificial kidney,WAK)是透析设备的进化产物,发展WAK的关键是从废透析液中去除尿毒症溶质,其中尿素是最难去除的尿毒症溶质。通过调研国内外WAK尿素去除技术进展,分别对脲酶去除尿素技术、电氧化技术和尿素吸附技术进行综述,首先简要介绍其原理,然后分析其在WAK临床试验中的应用及尿素去除效果,最后对3种技术进行优缺点评价并进行展望,期望对WAK尿素去除技术研究者给予相关信息支持和参考。

Wearable artificial kidney(WAK)is an evolutionary product of dialysis equipment.The key to develop WAK is to remove uremic solutes from waste dialysis fluid,in which urea is the most difficult uremic solute to be cleared.After investigating the progresses of urea removal technology of WAK in China and foreign countries,this paper reviews the urease urea removal technology,electrooxidation technology and urea adsorption technology.Their principles are briefly introduced,and the urea removal effects in clinical trials of WAK are analyzed.Finally,the advantages and disadvantages of the three technologies are evaluated and prospected.It is expected to provide relevant support and reference information of WAK to the urea removal technology researchers.