抗Xa因子活性检测在血液透析患者低分子肝素抗凝中的应用进展

Application of anti-Xa factor activity assay in low molecular weight heparin anticoagulation in hemodialysis patients

低分子肝素(low molecular weight heparin,LMWH)是普遍应用的抗凝剂之一,临床常通过抗Xa因子活性来监测其抗凝效应以及评估出血风险,合理的抗Xa因子活性区间在临床指南也都有相应推荐。而具体到血液透析患者中,使用LMWH抗凝时抗Xa因子的监测目标范围尚未形成共识,本综述主要论述抗Xa因子活性检测在血液透析LMWH抗凝中的应用价值,以及具体监测策略的研究进展。

Low molecular weight heparin(LMWH)is one of the commonly used anticoagulants.Its anticoagulation effect and bleeding risk are often monitored by the anti-Xa factor activity.Appropriate anti-Xa factor activity range is also recommended in clinical guidelines.As for hemodialysis patients using LMWH,there is no consensus about the target range of anti-Xa factor activity.This review mainly discusses the value of antiXa factor activity assay in LMWH anticoagulation for hemodialysis and the recent progresses in its specific monitoring strategies.