摘要
抗菌药物的药代动力学/药效动力学研究充分考虑宿主、病原体和药物三者的相互关系,反映抗菌药物疗效及不良反应与药物浓度变化之间的关系,对合理应用抗菌药物和延缓细菌耐药具有重要价值。本文基于药代动力学/药效动力学相关理论,探讨抗感染治疗中抗菌药物方案的设计与优化。
Pharmacokinetics/pharmacodynamics study fully considers the relationship among pathogens,hosts and drugs,which reflects the relationship between bactericidal effects and adverse drug reactions and the change of drug concentrations,which is of much value to the rational use of antimicrobial agents and delaying antimicrobial resistance.This review discussed design and optimization of dosing regimens for anti-infective therapy base on theory of pharmacokinetics/pharmacodynamics.
作者
杨梅
钱素云
Yang Mei;Qian Suyun(Department of Pharmacy,National Center for Children′s Health,Beijing Children′s Hospital,Capital Medical University,Beijing 100045,China;Pediatric Intensive Care Unit,National Center for Children′s Health,Beijing Children′s Hospital,Capital Medical University,Beijing 100045,China)
出处
《中国小儿急救医学》
CAS
2022年第4期246-249,共4页
Chinese Pediatric Emergency Medicine
基金
国家临床重点专科建设项目
北京市科委首都临床诊疗技术研究及转化应用(Z211100002921063)。
关键词
药代动力学
药效动力学
抗菌药物
感染
方案优化
Pharmacokinetics
Pharmacodynamics
Antibiotics
Infections
Optimization of dosing regimens
