低分子肝素联合阿司匹林对PTS致复发性流产母婴结局及血栓检验性指标的影响

The Effect of Low Molecular Weight Heparin Combined with Aspirin on the Maternal and Infant Outcome of PTS-induced Recurrent Miscarriage and Thrombus Test Indicators

目的 探究低分子肝素联合阿司匹林对PTS致复发性流产母婴结局及血栓检验性指标的影响。方法 纳入86例PTS致复发性流产在本院治疗的患者,(时间:2019年12月~2020年12月),行治疗对比性研究,电脑排列数组分组,对照组(阿司匹林治疗,n=43),实验组(低分子肝素联合阿司匹林治疗,n=43),分析两组患者(1)血栓检测指标水平(D-二聚体(D-Dimer)、凝血酶时间(TT)、狼疮样抗凝物质(LA)与正常值对比(LAR));(2)妊娠结局对比;(3)新生儿健康状况。(4)药物不良反应发生率(腹胀、腹泻、恶心呕吐、血小板减少、新生儿畸形)。结果 (1)血栓检测指标水平:实验组D-Dimer、TT、LAR,较对照组差异显著,(P<0.05);(2)妊娠结局:实验组较对照组,改善显著,(P<0.05);(3)新生儿健康状况:实验组较对照组,分娩孕周、出生体重、Apgar评分无明显差异,(P>0.05)。(4)药物不良反应发生率:实验组腹胀、腹泻、恶心呕吐、血小板减少、新生儿畸形等药物不良反应发生率较对照组,数据存在显著降低意义,(P>0.05)。结论 低分子肝素联合阿司匹林对PTS致复发性流产患者,有较好的治疗效果,改善母婴结局以及血栓检验性指标,有临床推广意义。

Objective To explore the effect of low molecular weight heparin combined with aspirin on maternal and infant outcomes and thrombosis test indicators of recurrent miscarriage caused by PTS.Methods A total of 86 patients with PTS-induced recurrent miscarriage treated in our hospital were included(time:December 2019 to December 2020) for a comparative study of treatment,grouped by computer array,and the control group(aspirin treatment,n=43),the experimental group(low molecular weight heparin combined with aspirin,n=43),the two groups of patients were analyzed(1) thrombus detection index levels(D-dimer(D-Dimer),thrombin time(TT),lupus-like Comparison of anticoagulant substances(LA) and normal values(LAR));(2) comparison of pregnancy outcomes;(3) neonatal health status.(4) The incidence of adverse drug reactions(abdominal distention,diarrhea,nausea and vomiting,thrombocytopenia,neonatal malformation).Results(1) Thrombus detection index levels:D-Dimer,TT,LAR in the experimental group were significantly different from those in the control group(P<0.05);(2) Pregnancy outcome:the experimental group was significantly improved compared with the control group(P<0.05);(3) Neonatal health status:There was no significant difference in gestational age,birth weight and Apgar score between the experimental group and the control group(P>0.05).(4) Incidence of adverse drug reactions:The incidence of adverse drug reactions such as abdominal distension,diarrhea,nausea and vomiting,thrombocytopenia,and neonatal malformation in the experimental group was significantly lower than that in the control group(P>0.05).Conclusions Low molecular weight heparin combined with aspirin has a good therapeutic effect on patients with recurrent miscarriage caused by PTS,improves maternal and infant outcomes and thrombus test indicators,and is of clinical significance.