孤独症谱系障碍儿童睡眠问题及其与褪黑素相关性研究进展

Research advances on the relationship between melatonin and sleep problems in children with autism spectrum disorder

孤独症谱系障碍(ASD)是一组神经发育障碍性疾病,常伴有的昼夜节律失常和睡眠问题,睡眠问题不仅可能加重ASD儿童的某些核心症状,还可能影响康复训练效果。ASD儿童睡眠问题的临床表现形式多样,但确切机制尚不明确,研究发现其与褪黑素分泌代谢异常密切相关,且褪黑素治疗有效、安全。本文主要对ASD儿童睡眠问题及其与褪黑素相关研究进展作一综述,旨在为改善ASD儿童睡眠问题以及制定有效的干预方案提供依据。

Autism spectrum disorder(ASD) is a group of neurodevelopmental disorders, often accompanied by circadian rhythm disorders and sleep problems. Sleep problems may not only aggravate some of the core symptoms of ASD children, but also affect the effect of rehabilitation training. The clinical manifestations of sleep problems in ASD children are various, but the exact mechanism is not clear. Studies have found that it is closely related to abnormal melatonin secretion and metabolism, and melatonin treatment is effective and safe. This paper mainly reviews the sleep problems of ASD children and the research progress related to melatonin in order to provide basis for improving sleep quality of ASD children and formulating effective intervention programs.