摘要
Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic performance.But,low in-depth tissue penetration of light limits their effectivity for deeply buried tumors.Encouraged by the sonosensitizing ability of the traditional organic photosensitizers,here,we developed AuNPs@Ir1 as a sonosensitizer by hybridizing an organometallic Ir(Ⅲ) complex(Ir1) with ultrasmall gold nanoparticles(AuNPs) for efficient tumor sonodynamic therapy(SDT) for the first time.AuNPs@Ir1 rapidly entered the cancer cells,produced ^(1)O_(2),and catalytically oxidized NADH to NAD;under ultrasound(US)irradiation,thus resulted in cancer cells oncosis.Because of efficient passive retention in tumors post intravenous injection,AuNPs@Ir1 further efficiently inhibited the growth of tumors in-vivo under US stimulation without long-term toxicity to other organs.Overall,this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel AuNPs@Ir1.It is expected to increase the scope of SDT for metal-based anticancer drugs.
基金
financial support of the National Natural Science Foundation of China (NSFC, Nos. 22077085, 22007104)
the Project of the Natural Science Foundation of Guangdong Province(No. 2019A1515011958)
the Science and Technology Foundation of Shenzhen (No. JCYJ20190808153209537)
DST,the Government of India (No. DST/INSPIRE/04/2019/000492)
the Instrumental Analysis Center of Shenzhen University。
