鱼腥草滴眼液联合夫西地酸滴眼液治疗急性细菌性结膜炎的临床研究

Clinical study on Yuxingcao Eye Drops combined with Fusidic Acid Eye Drops in treatment of acute bacterial conjunctivitis

目的探讨鱼腥草滴眼液联合夫西地酸滴眼液治疗急性细菌性结膜炎的临床效果。方法选取2019年1月—2020年12月河南科技大学第一附属医院收治的160例急性细菌性结膜炎患者,随机分成对照组和治疗组,每组各80例。对照组患眼眼睑内滴入夫西地酸滴眼液,1滴/次,2次/d。在对照组基础上,治疗组给予鱼腥草滴眼液,1滴/次,6次/d。两组均连续治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者典型表现缓解时间,Schirmer I试验(SIt)值和泪膜破裂时间(BUT),及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-18)和超敏C反应蛋白(hs-CRP)水平。结果治疗后,治疗组临床有效率为97.50%,较对照组的88.75%显著提高(P<0.05)。与对照组相比,治疗组灼热感、异物感、结膜分泌物和结膜充血的缓解时间均显著缩短(P<0.05)。治疗后,治疗组SIt值显著增加,BUT显著延长(P<0.05);而对照组SIt值显著减小,BUT显著缩短(P<0.05)。治疗后,治疗组SIt值和BUT均显著优于对照组(P<0.05)。治疗后,两组患者血清TNF-α、IL-18和hs-CRP浓度较治疗前均显著下降(P<0.05),且治疗组较对照组更低(P<0.05)。结论鱼腥草滴眼液联合夫西地酸滴眼液治疗急性细菌性结膜炎的整体疗效确切,可安全有效,且迅速地改善患者眼部表现。

Objective To investigate the clinical effect of Yuxingcao Eye Drops combined with Fusidic Acid Eye Drops in treatment of acute bacterial conjunctivitis.Methods Patients(160 cases)with acute bacterial conjunctivitis in the First Affiliated Hospital of Henan University of Science and Technology from January 2019 to December 2020 were randomly divided into control and treatment group,and each group had 80 cases.Patients in the control group were administered with Fusidic Acid Eye Drops in the affected eye of intraeyelid,1 drop/time,twice daily.Patients in the treatment group were po administered with Yuxingcao Eye Drops on the basis of the control group,1 drop/time,six times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluation was evaluated,the remission time of typical performance,SⅠt and BUT,the levels of serum TNF-α,IL-18 and hs-CRP in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 97.50%,which was significantly higher than that of the control group(88.75%)(P<0.05).Compared with the control group,the relief time of burning sensation,foreign body sensation,conjunctival secretion and conjunctival congestion in the treatment group was significantly shortened(P<0.05).After treatment,SIt value in the treatment group was significantly increased,BUT significantly prolonged(P<0.05).In the control group,SIt value decreased significantly,BUT decreased significantly(P<0.05).After treatment,the SIt value and BUT in the treatment group were significantly better than those of the control group(P<0.05).After treatment,the levels of serum TNF-α,IL-18 and hs-CRP in two groups were significantly lower than those before treatment(P<0.05),and which in the treatment group were lower than those in the control group(P<0.05).Conclusion The overall curative effect of Yuxingcao Eye Drops combined with Fusidic Acid Eye Drops in treatment of acute bacterial conjunctivitis is accurate,and which can safely,effectively and rapidly improve the eye performance of patients.