塞来昔布抗肿瘤效应及其作用机制的研究进展

Research progress on anti-tumor effect and its mechanism of celecoxib

塞来昔布是一种特异性环氧化酶-2抑制剂,具有抗炎、镇痛和退热作用。近年来,塞来昔布的抗肿瘤作用受到广泛关注,已被应用于消化道肿瘤、乳腺癌、肺癌、肝癌、前列腺癌等的化学辅助治疗和放射治疗增敏。综述了塞来昔布的抗肿瘤效应,并总结了其作用机制,如抑制肿瘤细胞增殖、抑制肿瘤细胞侵袭和转移、抑制肿瘤新生血管生成、诱导肿瘤细胞分化、诱导肿瘤细胞凋亡、调节肿瘤免疫、逆转肿瘤细胞的多药耐药性,以期为塞来昔布的深入研究和临床肿瘤防治提供用药参考。

Celecoxib is a specific cyclooxygenase-2 inhibitor,and has anti-inflammatory,analgesic,and antipyretic effects.In recent years,the antitumor effect of celecoxib has received extensive attention,and has been applied to adjuvant chemotherapy and radiotherapy for gastrointestinal cancer,breast cancer,lung cancer,liver cancer,prostate cancer,and so on.This article reviews the antitumor effect of celecoxib and summarizes its mechanism,such as inhibiting tumor cell proliferation,inhibiting tumor cell invasion and metastasis,inhibiting tumor angiogenesis,inducing tumor cell differentiation,inducing tumor cell apoptosis,regulating tumor immunity,and reversing multidrug resistance of tumor cells,in order to provide drug reference for further research and clinical tumor prevention and treatment of celecoxib.